Publication: Endotel progenitör hücreler
Abstract
Endotelyal progenitör hücreler (EPH) gelecek yıllarda vasküler hastalıkların tedavi yöntemleri arasına girmeye adaydır. Postnatal süreçte de fonksiyonlarını devam ettirdikleri kanıtlanan EPH’ler kemik iliğinde olgunlaşıp, dolaşıma çıkarak vasküler hasarın olduğu bölgelerde yoğunlaşıp hasarın tamir edilmesinde merkezi rol alırlar. EPH’ler kemik iliğinden ayrıldıktan sonra hücre yüzey belirteçlerinde birtakım değişiklikler geçirerek olgun endotel hücrelere dönüşebilirler. Günümüzde EPH’lerle ilişkili hem klinik hem de deneysel çalışmalar oldukça artmıştır. Fakat EPH’lerin olgunlaşmasını, göçünü ve hasarlı bölgeye yerleşmesini sağlayan mekanizmalar tam olarak aydınlatılmış değildir.
Endothelial progenitor cells (EPCs) are candidate for, to be a treatment option for vascular diseases. It has been proven that EPCs preserve their functions in the postnatal period. EPCs mature in bone marrow, enter peripheral circulation then gather at the site of vascular injury to take a central role in repair process. After they leave bone marrow the cell surface markers of them can change and they can differentiate to mature endothelial cells. At the present time clinical and experimental studies about EPCs fairly increase. But the mechanisms which enable EPCs to mature, migrate and home at the site of injury had not yet been enlightened.
Endothelial progenitor cells (EPCs) are candidate for, to be a treatment option for vascular diseases. It has been proven that EPCs preserve their functions in the postnatal period. EPCs mature in bone marrow, enter peripheral circulation then gather at the site of vascular injury to take a central role in repair process. After they leave bone marrow the cell surface markers of them can change and they can differentiate to mature endothelial cells. At the present time clinical and experimental studies about EPCs fairly increase. But the mechanisms which enable EPCs to mature, migrate and home at the site of injury had not yet been enlightened.