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Synthesis and antituberculosis activity of new N-phenyl-N '-[4-(5-alkyl/arylamino-1,3,4-thiadiazole-2-yl)phenyl]thioureas

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dc.contributor.authorsKarakus, S; Rollas, S
dc.date.accessioned2022-03-12T15:58:15Z
dc.date.accessioned2026-01-10T19:07:59Z
dc.date.available2022-03-12T15:58:15Z
dc.date.issued2002
dc.description.abstractIn this study, eight original N-phenyl-N'-[4-(5-alkyl/arylamino-1,3,4-thiadiazole-2-yl)phenyl]thiourea, derivatives were synthesized and tested for antituberculosis activity. Antituberculosis activities of the synthesized compounds were screened in vitro using BACTEC 460 Radiometric System against Mycobacterium tuberculosis H37Rv at 6.25 mug/ml. The highest inhibition observed with the synthesized compounds is 67% for N-phenyl-N'-[4-(5-cyclohexylamino-1,3,4-thiadiazole-2-yl)phenyl]thiourea. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
dc.identifier.doi10.1016/S0014-827X(02)01252-1
dc.identifier.issn0014-827X
dc.identifier.pubmed12164218
dc.identifier.urihttps://hdl.handle.net/11424/224002
dc.identifier.wosWOS:000177620000014
dc.language.isoeng
dc.publisherELSEVIER SCIENCE SA
dc.relation.ispartofFARMACO
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject1,3,4-thiadiazole
dc.subjectthiourea
dc.subjectantituberculosis activity
dc.titleSynthesis and antituberculosis activity of new N-phenyl-N '-[4-(5-alkyl/arylamino-1,3,4-thiadiazole-2-yl)phenyl]thioureas
dc.typeconferenceObject
dspace.entity.typePublication
oaire.citation.endPage581
oaire.citation.issue7
oaire.citation.startPage577
oaire.citation.titleFARMACO
oaire.citation.volume57

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