Publication:
Antituberculosis activity of hydrazones derived from 4-fluorobenzoic acid hydrazide

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dc.contributor.authorKAYMAKÇIOĞLU, BEDİA
dc.contributor.authorsKocyigit-Kaymakcioglu, Bedia; Oruc-Emre, Emine Elcin; Unsalan, Seda; Rollas, Sevim
dc.date.accessioned2022-03-12T17:46:40Z
dc.date.accessioned2026-01-11T18:44:15Z
dc.date.available2022-03-12T17:46:40Z
dc.date.issued2009
dc.description.abstractA series of substitututed methylene/ethylene 4-fluorophenylhydrazide derivatives (3a-p) was synthesized with the aim of evaluating their antimycobacterial activity toward a strain of Mycobacterium tuberculosis H37Rv. Their chemical structures were confirmed by H-1-nuclear magnetic resonance (NMR) and electrospray mass spectrometry (ES-MS) spectral data, and elemental analysis. The in vitro antimycobacterial evaluation was performed according to the Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF) antituberculosis drug discovery program. Compound 3a, 4-fluorobenzoic acid [(2,6-dichlorophenyl) methylene]hydrazide, showed the highest inhibitory activity of all the compounds under study.
dc.identifier.doi10.1007/s00044-008-9126-z
dc.identifier.eissn1554-8120
dc.identifier.issn1054-2523
dc.identifier.urihttps://hdl.handle.net/11424/229491
dc.identifier.wosWOS:000265569300004
dc.language.isoeng
dc.publisherSPRINGER BIRKHAUSER
dc.relation.ispartofMEDICINAL CHEMISTRY RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHydrazide-hydrazones
dc.subjectAntituberculosis activity
dc.subject4-fluorobenzoic acid hydrazide
dc.subjectANTIMYCOBACTERIAL ACTIVITY
dc.subjectANTIMICROBIAL ACTIVITY
dc.subjectTUBERCULOSIS
dc.subjectDERIVATIVES
dc.titleAntituberculosis activity of hydrazones derived from 4-fluorobenzoic acid hydrazide
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage286
oaire.citation.issue4
oaire.citation.startPage277
oaire.citation.titleMEDICINAL CHEMISTRY RESEARCH
oaire.citation.volume18

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