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The Application of Differential Pulse Polarography to the Analysis of Capecitabine and Investigation of Its Electroreduction Mechanism

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dc.contributor.authorÇELİK, MELEK ŞİRİN
dc.contributor.authorsBaymak, Melek Sirin; Celik, Hayati; Ozkan, Sibel A.
dc.date.accessioned2022-03-12T20:26:33Z
dc.date.accessioned2026-01-11T15:19:18Z
dc.date.available2022-03-12T20:26:33Z
dc.date.issued2015
dc.description.abstractThe investigation of electrochemical reduction of capecitabine on DME resulted in a reduction scheme that involves a two electron reduction of the C=O bond on the six membered heterocyclic ring and comparison with model compounds such as benzophenone, 5-fluorouracil and cytosine supported the observed behavior. Reporting an inexpensive, simple, rapid and validated method for determination of capecitabine was achieved by DPP with good precision, accuracy and reproducibility. This work emphasizes polarography to be the best method of choice when studying reduction mechanisms and presents an example of its use for electroanalytical purposes. (C) 2015 The Electrochemical Society. All rights reserved.
dc.identifier.doi10.1149/2.0021507jes
dc.identifier.eissn1945-7111
dc.identifier.issn0013-4651
dc.identifier.urihttps://hdl.handle.net/11424/233482
dc.identifier.wosWOS:000353009300093
dc.language.isoeng
dc.publisherELECTROCHEMICAL SOC INC
dc.relation.ispartofJOURNAL OF THE ELECTROCHEMICAL SOCIETY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMASS-SPECTROMETRY
dc.subjectMETABOLITES
dc.subjectPHARMACOKINETICS
dc.subjectFLUOROPYRIMIDINE
dc.subject5-FLUOROURACIL
dc.subjectDRUG
dc.titleThe Application of Differential Pulse Polarography to the Analysis of Capecitabine and Investigation of Its Electroreduction Mechanism
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPageG35
oaire.citation.issue6
oaire.citation.startPageG29
oaire.citation.titleJOURNAL OF THE ELECTROCHEMICAL SOCIETY
oaire.citation.volume162

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