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Zeolite 4A as a jammer of bacterial communication in chromobacterium violaceum and pseudomonas aeruginosa

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dc.contributor.authorTINAZ, GÜLGÜN
dc.contributor.authorsULUSOY S., B Akalin R., cevikbas H., Berisha A., ORAL A., TINAZ G.
dc.date.accessioned2023-06-19T07:52:39Z
dc.date.accessioned2026-01-11T13:33:25Z
dc.date.available2023-06-19T07:52:39Z
dc.date.issued2022-07-01
dc.description.abstractAim: To investigate the hypothesis that zeolites interfere with quorum-sensing (QS) systems of Chromobacterium violaceum and Pseudomonas aeruginosa by adsorbing N-acyl homoserine lactone (AHL) signal molecules. Methods: QS inhibition by zeolite 4A was investigated using an AHL-based bioreporter assay. The adsorption of the AHLs was evaluated by performing inductively coupled plasma-optical emission spectroscopy and confirmed by Monte Carlo and molecular dynamic simulations. Results: Zeolite 4A reduced the violacein production in C. violaceum by over 90% and the biofilm formation, elastase and pyocyanin production in P. aeruginosa by 87, 68 and 98%, respectively. Conclusion: Zeolite 4A disrupts the QS systems of C. violaceum and P. aeruginosa by means of adsorbing 3-oxo-C6-AHL and 3-oxo-C12-AHL signaling molecules and can be developed as a novel QS jammer to combat P. aeruginosa-related infections.
dc.identifier.citationULUSOY S., B Akalin R., cevikbas H., Berisha A., ORAL A., TINAZ G., "Zeolite 4A as a jammer of bacterial communication in Chromobacterium violaceum and Pseudomonas aeruginosa", FUTURE MICROBIOLOGY, cilt.17, ss.861-871, 2022
dc.identifier.doi10.2217/fmb-2021-0174
dc.identifier.endpage871
dc.identifier.issn1746-0913
dc.identifier.startpage861
dc.identifier.urihttps://hdl.handle.net/11424/290403
dc.identifier.volume17
dc.language.isoeng
dc.relation.ispartofFUTURE MICROBIOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectLife Sciences
dc.subjectNatural Sciences
dc.subjectMikrobiyoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMICROBIOLOGY
dc.subjectLife Sciences (LIFE)
dc.subjectbiofilms
dc.subjectmodeling
dc.subjectPseudomonas aeruginosa
dc.subjectquorum sensing
dc.subjectQUORUM SENSING INHIBITORS
dc.subjectBIOFILM FORMATION
dc.subjectESSENTIAL OILS
dc.subjectGENES
dc.subjectDERIVATIVES
dc.subjectADSORPTION
dc.subjectEXPRESSION
dc.subjectVIRULENCE
dc.subjectENZYME
dc.subjectSTEEL
dc.titleZeolite 4A as a jammer of bacterial communication in chromobacterium violaceum and pseudomonas aeruginosa
dc.typearticle
dspace.entity.typePublication

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