Publication:
Comparison of Optical Coherence Tomography Findings in Patients With Primary Open-angle Glaucoma and Parkinson Disease

dc.contributor.authorsEraslan, Muhsin; Balci, Sevcan Y.; Cerman, Eren; Temel, Ahmet; Suer, Devran; Elmaci, Nese T.
dc.date.accessioned2022-03-12T20:28:15Z
dc.date.accessioned2026-01-10T21:49:57Z
dc.date.available2022-03-12T20:28:15Z
dc.date.issued2016
dc.description.abstractPurpose: To evaluate the peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex, and macular thickness as well as their correlation with the severity of diseases. Materials and Methods: This is a cross-sectional study and comparing both eyes of 26 patients with primary open-angle glaucoma, 25 patients with Parkinson disease (PD), and 23 healthy subjects. RNFL, ganglion cell complex, and macular thickness were measured and analyzed with optical coherence tomography (OCT) in all cases and correlation with severity of the disease was assessed in PD group. Results: The mean RNFL of PD was significantly thinner compared with controls (P=0.002). In glaucoma group, the mean RNFL was significantly thinner (96.28+/-12.49 mm) than PD (105.43+/-13.45 mm) and the controls (113.75+/-8.53 mm) (P<0.001; P<0.001, respectively). The global loss volume (GLV) rates in the glaucoma and PD group were significantly higher than controls, respectively (P=0.006; P<0.001/P=0.002, P=0.013). However, the GLV rate was significantly lower in PD group compared with glaucoma group (P=0.001). There was no significant correlation between OCT measurements and disease duration or severity in the PD patients. Conclusions: Although RNFL thickness and GLV changes may show the ganglion cell loss in both disease but none of the OCT parameters are correlated with the severity of PD. OCT may help to reveal the ganglion cell damage but may not help in determination of severity during the clinical follow-up of PD patients.
dc.identifier.doi10.1097/IJG.0000000000000239
dc.identifier.eissn1536-481X
dc.identifier.issn1057-0829
dc.identifier.pubmed25719240
dc.identifier.urihttps://hdl.handle.net/11424/233878
dc.identifier.wosWOS:000379585100002
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.relation.ispartofJOURNAL OF GLAUCOMA
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectoptical coherence tomography
dc.subjectneurodegenerative disorders
dc.subjectganglion cell complex
dc.subjectFIBER LAYER THICKNESS
dc.subjectRETINAL THICKNESS
dc.subjectGANGLION-CELL
dc.subjectEVOKED-POTENTIALS
dc.subjectDOPAMINE
dc.subjectELECTRORETINOGRAMS
dc.subjectIMPAIRMENT
dc.subjectDECREASES
dc.subjectAPOPTOSIS
dc.titleComparison of Optical Coherence Tomography Findings in Patients With Primary Open-angle Glaucoma and Parkinson Disease
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPageE646
oaire.citation.issue7
oaire.citation.startPageE639
oaire.citation.titleJOURNAL OF GLAUCOMA
oaire.citation.volume25

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