Publication:
CALCIUM-CHANNEL BLOCKERS PREVENT STRESS-INDUCED ULCERS IN RATS

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Date

1992

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BIRKHAUSER VERLAG AG

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Abstract

Gastric mucosal damage induced by cold and restraint stress caused increase in gastric lipid peroxidation (LP) and decrease in gastric glutathione levels. Two calcium-channel blockers, verapamil and nicardipine, prevented stress-induced increase in gastric LP, as well as ulcer formation. Both calcium-channel blockers protected against stress-induced ulcers, and inhibition of LP may be among their mechanisms of action.

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GASTRIC-MUCOSAL LESIONS, LIPID-PEROXIDATION, ACID-SECRETION, GLUTATHIONE, ETHANOL, DAMAGE, VERAPAMIL, ANTAGONISTS, ANTIOXIDANT, INHIBITION

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https://hdl.handle.net/11424/226488

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