Publication: Kardiyopulmoner baypas uygulanan endokardiyal yastık defektli pediyatrik olgularda modifiye ultrafiltrasyonun interlökin-6, interlökin-8 ve tnf-alfa düzeylerine etkisi
Abstract
Amaç: Bu çalışmanın amacı; KPB yapılan atriyal, ventriküler ve atriyoventriküler septal defektli pediyatrik hastalarda modifiye ultrafiltrasyonun interlökin-6, interlökin-8 ve TNF-alfa düzeylerine etkisini saptamaktır. Gereç ve Yöntem: Çalışmamızda, 3 yaşından küçük, 10 kg altındaki, Endokardiyal Yastık Defektli, elektif açık kalp cerrahi geçirecek pediyatrik olgular MUF uygulanan (Grup 1, n=17) ve MUF uygulanmayan (Grup 2, n=17) olarak randomize iki gruba ayrıldı. Tüm olgulara kardiyopulmoner baypas sonrasında UF uygulandı ve postoperatif 24. saatteki IL-6, IL-8, TNF alpha düzeyleri karşılaştırıldı. Tüm olguların demografik özellikleri, hemodinamik, laboratuvar değerleri ile postoperatif 24 saatlik klinik takip parametreleri kaydedildi. Veriler SPSS 22.0 analiz edildi. Bulgular: Çalışmada gruplar arası IL-6, IL-8 ve TNF-Alfa düzeylerinin karşılaştırılmasında istatistiksel olarak anlamlı fark olmadığı saptandı. Sonuçlar: Bu çalışmada MUF uygulamasının IL-6, IL-8 ve TNF-Alfa düzeylerinde MUF uygulanmayan hastalara göre anlamlı bir farklılık yaratmadığı sonucuna ulaşıldı. Çalışma sonuçlarının daha iyi değerlendirilmesi için benzer daha fazla çalışma yapılması önerilir.
Objective: The aim of this study was to determine the effect of modified ultrafiltration (MUF) on interleukin-6, interleukin-8, and tumor necrosis factor-alpha (TNF-α) levels in pediatric patients with atrial, ventricular, and atrioventricular septal defects undergoing cardiopulmonary bypass (CPB). Materials and Methods: In the study, pediatric cases under 3 years age of, weighing less than 10 kg, with endocardial cushion defects scheduled for elective open-heart surgery were randomly divided into two groups: MUF applied (Group 1, n=17) and MUF not applied (Group 2, n=17). All cases received ultrafiltration (UF) after cardiopulmonary bypass, and IL-6, IL-8, and TNF-alpha levels were compared at 24 hours postoperatively. Demographic characteristics, hemodynamic and laboratory values, and clinical parameters during the 24-hours postoperative follow-up, were recorded for all cases. Data were analyzed using SPSS 22.0 software. Results: No statistically significant difference wre observed in the comparison of IL-6, IL-8, and TNF-alpha levels between the groups. Conclusion: This study found that the application of MUF did not result in a significant difference in IL-6, IL-8, and TNF-alpha levels compared to patients without MUF. Further studies with similar designs are recommended to better evaluate of the results.
Objective: The aim of this study was to determine the effect of modified ultrafiltration (MUF) on interleukin-6, interleukin-8, and tumor necrosis factor-alpha (TNF-α) levels in pediatric patients with atrial, ventricular, and atrioventricular septal defects undergoing cardiopulmonary bypass (CPB). Materials and Methods: In the study, pediatric cases under 3 years age of, weighing less than 10 kg, with endocardial cushion defects scheduled for elective open-heart surgery were randomly divided into two groups: MUF applied (Group 1, n=17) and MUF not applied (Group 2, n=17). All cases received ultrafiltration (UF) after cardiopulmonary bypass, and IL-6, IL-8, and TNF-alpha levels were compared at 24 hours postoperatively. Demographic characteristics, hemodynamic and laboratory values, and clinical parameters during the 24-hours postoperative follow-up, were recorded for all cases. Data were analyzed using SPSS 22.0 software. Results: No statistically significant difference wre observed in the comparison of IL-6, IL-8, and TNF-alpha levels between the groups. Conclusion: This study found that the application of MUF did not result in a significant difference in IL-6, IL-8, and TNF-alpha levels compared to patients without MUF. Further studies with similar designs are recommended to better evaluate of the results.