Publication:
alpha-Melanocyte stimulating hormone has beneficial effects on cerulein-induced acute pancreatitis

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dc.contributor.authorsJahovic, N; Arbak, S; Tekeli, O; Alican, I
dc.date.accessioned2022-03-12T17:16:19Z
dc.date.accessioned2026-01-10T16:56:16Z
dc.date.available2022-03-12T17:16:19Z
dc.date.issued2004
dc.description.abstractWe investigated the effect of alpha-melanocyte stimulating hormone (alpha-MSH) on cerulein induced acute pancreatitis in rats. alpha-MSH treatment (50 mug per rat, intraperitoneally) prior to cerulein reduced the plasma amylase level, pancreatic weight, pancreatic myeloperoxidase activity and the severity of the lesions microscopically. These data suggest that a-MSH has a protective effect on cerulein-induced acute pancreatitis and this effect could be attributed, at least in part, to decreased tissue leukocyte infiltration and thus, to decreased pro-inflammatory cytokine production and/or oxygen- and nitrogen-derived reactive metabolite release. (C) 2004 Elsevier Inc. All nights reserved.
dc.identifier.doi10.1016/j.peptides.2003.11.008
dc.identifier.eissn1873-5169
dc.identifier.issn0196-9781
dc.identifier.pubmed15003365
dc.identifier.urihttps://hdl.handle.net/11424/227522
dc.identifier.wosWOS:000220267900017
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofPEPTIDES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectpancreatitis
dc.subjectalpha-melanocyte stimulating hormone
dc.subjectneutrophils
dc.subjectrat
dc.subjectNF-KAPPA-B
dc.subjectINFLAMMATION
dc.subjectMSH
dc.subjectMODULATION
dc.subjectADHESION
dc.subjectINJURY
dc.subjectRAT
dc.titlealpha-Melanocyte stimulating hormone has beneficial effects on cerulein-induced acute pancreatitis
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage132
oaire.citation.issue1
oaire.citation.startPage129
oaire.citation.titlePEPTIDES
oaire.citation.volume25

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