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Determination of pK(a) Values of Some Benzoxazoline Derivatives and the Structure-Activity Relationship

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dc.contributor.authorÇELİK, MELEK ŞİRİN
dc.contributor.authorsCelik, Hayati; Buyukaga, Mahmure; Celebier, Mustafa; Acar, Ebru Turkoz; Baymak, Melek Sirin; Gokhan-Kelekci, Nesrin; Palaska, Erhan; Erdogan, Hakki
dc.date.accessioned2022-03-13T12:44:20Z
dc.date.accessioned2026-01-11T06:10:18Z
dc.date.available2022-03-13T12:44:20Z
dc.date.issued2013
dc.description.abstractThe acid ionization constant (pK(a)) values of 2-(3H)-benzoxazolinone and its 17 derivatives were determined in buffered solutions by UV-vis spectrophotometry, potentiometry, and capillary zone electrophoresis techniques. The pK(a) values of the studied compounds are found to be in the range of 9.01 to 7.15. The advantages and limitations of each technique are discussed. The results suggest that the removal of a proton from the molecule occurred on the nitrogen atom of the 2-(3H)-benzoxazolinone ring and the analgesic/anti-inflammatory activities of the benzoxazolinone derivatives decrease when the pK(a) values of the compounds increase.
dc.identifier.doi10.1021/je3012919
dc.identifier.eissn1520-5134
dc.identifier.issn0021-9568
dc.identifier.urihttps://hdl.handle.net/11424/237485
dc.identifier.wosWOS:000320641100021
dc.language.isoeng
dc.publisherAMER CHEMICAL SOC
dc.relation.ispartofJOURNAL OF CHEMICAL AND ENGINEERING DATA
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectANALGESIC ACTIVITY
dc.subjectMANNICH-BASES
dc.subjectELECTROPHORESIS
dc.subjectDAMAGE
dc.titleDetermination of pK(a) Values of Some Benzoxazoline Derivatives and the Structure-Activity Relationship
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage1596
oaire.citation.issue6
oaire.citation.startPage1589
oaire.citation.titleJOURNAL OF CHEMICAL AND ENGINEERING DATA
oaire.citation.volume58

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