Publication: Antinociceptive effects of morphine and physostigmine in different inbred strains of mice
| dc.contributor.authors | Aslan A.N., Berkman K., Cirakoglu B., Oktay S. | |
| dc.date.accessioned | 2022-03-28T14:50:10Z | |
| dc.date.accessioned | 2026-01-10T20:25:02Z | |
| dc.date.available | 2022-03-28T14:50:10Z | |
| dc.date.issued | 1996 | |
| dc.description.abstract | Antinociceptive effects of morphine and physostigmine, alone or in combination were investigated in mice of BALB/C, C57BL/6 and CB6F1 strains. Morphine and physostigmine increased pain treshold in BALB/C and CB6F1 mice at a dose of 5 mg/kg and 0.1 mg/kg, respectively, whereas C57BL/6 mice were found to be less responsive to both agents. When a nonanalgesic dose of physostigmine (0.05 mg/kg) was combined with a nonanalgesic dose of morphine (2.5 mg/kg), a significant antinociceptive effect was observed in BALB/C and CB6F1 mice, but not in C57BL/6 strain. These results suggest that there is a significant influence of strain on cholinergic and opioid antinociception, and synergistic interaction between cholinergic and opioidergic systems also occur strain-dependently. | |
| dc.identifier.issn | 10191941 | |
| dc.identifier.uri | https://hdl.handle.net/11424/255346 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | Marmara Medical Journal | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | Analgesia | |
| dc.subject | BALB/C | |
| dc.subject | C57BL/6 | |
| dc.subject | CB6F1 | |
| dc.subject | Morphine | |
| dc.subject | Physostigmine | |
| dc.subject | Tail-flick | |
| dc.title | Antinociceptive effects of morphine and physostigmine in different inbred strains of mice | |
| dc.type | article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 10 | |
| oaire.citation.issue | 1 | |
| oaire.citation.startPage | 7 | |
| oaire.citation.title | Marmara Medical Journal | |
| oaire.citation.volume | 9 |