Publication: Synthesis and antituberculosis activity of 2-(aryl/alkylamino)-5-(4- aminophenyl)-1,3,4-thiadiazoles and their Schiff bases
| dc.contributor.authors | Solak N., Rollas S. | |
| dc.date.accessioned | 2022-03-28T14:53:32Z | |
| dc.date.accessioned | 2026-01-11T13:25:51Z | |
| dc.date.available | 2022-03-28T14:53:32Z | |
| dc.date.issued | 2006 | |
| dc.description.abstract | A series of new Schiff bases were synthesized through the condensation reaction of 1,3,4-thiadiazoles containing a aromatic primary amine and 3-hydroxybenzaldehyde, salicylaldehyde, 5-nitrofurfuraldehyde or 3-nitrobenzaldehyde. The synthesized compounds screened for antituberculosis activity against Mycobacterium tuberculosis H37Rv using BACTEC 460 radiometric system. Among the tested compounds, 2-phenylamino-5-[4-(2- hydroxybenzylideneamino)phenyl]-1,3,4-thiadiazol (5a) showed the highest inhibitory activity (51%). The activities of the synthesized Schiff bases were compared with those of the starting 2-(aryl/alkylamino)-5-(4-aminophenyl)-1,3,4- thiadiazoles (4a-e). Some Schiff bases showed higher growth inhibition than the starting amines. ©ARKAT. | |
| dc.identifier.issn | 14246376 | |
| dc.identifier.uri | https://hdl.handle.net/11424/256019 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | Arkivoc | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | 1,3,4-thiadiazoles | |
| dc.subject | Antituberculosis activity | |
| dc.subject | Schiff bases | |
| dc.subject | Synthesis | |
| dc.title | Synthesis and antituberculosis activity of 2-(aryl/alkylamino)-5-(4- aminophenyl)-1,3,4-thiadiazoles and their Schiff bases | |
| dc.type | article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 181 | |
| oaire.citation.issue | 12 | |
| oaire.citation.startPage | 173 | |
| oaire.citation.title | Arkivoc | |
| oaire.citation.volume | 2006 |