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MOISTURE ADSORPTION AND EFFECT OF ADSORBED WATER ON THE POWDER AND COMPACTION PROPERTIES OF RANITIDINE HYDROCHLORIDE

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dc.contributor.authorsUZUNARSLAN, K; AKBUGA, J
dc.date.accessioned2022-03-12T16:55:49Z
dc.date.accessioned2026-01-11T08:09:22Z
dc.date.available2022-03-12T16:55:49Z
dc.date.issued1991
dc.description.abstractMoisture adsorption properties of ranitidine hydrochloride were investigated. The amount of water adsorbed was very small up to 75% relative humidity (RH), however, after this value (critical RH), an abrupt increase was observed in the moisture adsorption. Addition of excipients changed the water uptake levels of drug. Furthermore moisture adsorption proportionally increased with the amount of Avicel(R) and corn starch. In the second part of this study the effect of adsorbed water on powder and compaction properties of ranitidine hydrochloride was studied. The powder and compaction properties of the drug were changed by water adsorption.
dc.identifier.doidoiWOS:A1991HL35200010
dc.identifier.issn0031-7144
dc.identifier.urihttps://hdl.handle.net/11424/226562
dc.identifier.wosWOS:A1991HL35200010
dc.language.isoeng
dc.publisherGOVI-VERLAG GMBH
dc.relation.ispartofPHARMAZIE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSTABILITY
dc.subjectSTRENGTH
dc.subjectTABLETS
dc.titleMOISTURE ADSORPTION AND EFFECT OF ADSORBED WATER ON THE POWDER AND COMPACTION PROPERTIES OF RANITIDINE HYDROCHLORIDE
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage275
oaire.citation.issue4
oaire.citation.startPage273
oaire.citation.titlePHARMAZIE
oaire.citation.volume46

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