Publication: Romatoid Artritte Tamamlayıcı ve_x000D_
Bütünleyici Tıp Uygulamalarının Dünü, Bugünü ve Yarını
Abstract
Romatoid artrit [rheumatoid arthritis (RA)], en sık görülen otoimmün eklem hastalıklarından birisidir. Toplumun yaklaşık %0,5-1’inietkileyen RA için mevcut hedefe yönelik tedavi protokolleri hastalık aktivitesini ölçer; konvansiyonel, steroid olmayan antiinflamatuar ilaçları[nonsteroidal anti-inflammatory drugs (NSAIDs)] ve metotreksat gibibiyolojik olmayan hastalık modifiye edici antiromatizmal ilaçları [disease-modifying antirheumatic drugs (DMARDs)] kullanır. Bununla birlikte tedavilerin bazılarına etkili şekilde yanıt vermeyen hastalar vardırve verilen ilaçlar hastaları tatmin etmemektedir. Bu nedenle acilen yeniçözümlere ihtiyaç duyulduğu açıktır. Son zamanlarda tamamlayıcı vealternatif tıp [complementary and alternative medicine(CAM)], RA tedavisinde son derece popülerdir. RA hastaları hayatlarında en az bir keztamamlayıcı tedavilere başvurmuştur. CAM, genellikle modern tedavilerin yerine geçmek yerine onlara ek ve destekleyici olarak kullanılır.Mevcut biyolojik ilaçların sınırlamaları ve yan etkileri yüzünden, RA'lıbirçok kişinin yüzünü CAM'a çevirmesi şaşırtıcı değildir. Aslında, bitkisel ilaçlar, diyet müdahalesi, manuel terapi, kalori kısıtlaması ve epigenomik yaklaşımlar kas-iskelet ağrısını azaltmada ümit vadetmektedir.Bu çalışmamız, RA tedavisinde CAM hakkında bilinenlere kısa birgenel bakış sağlar ve ayrıca yeşil çay, Tripterygium wilfordii, Curcumalonga, Veratrum grandiflorum ve Camellia sinensis gibi bitkilerin farmakolojik etkileri hakkında son bilgileri özetlemektedir. Bu derleme,ayrıca mikrobiyom, nütrigenomiks ve RA arasında bildirilen korelasyon ve altta yatan moleküler mekanizmaları da özetlemektedir. CAMtedavilerinin etkili olabileceği mekanizmaların derinlemesine anlaşılması ve netleştirilmesi RA semptomlarının azaltılmasında yeni moleküler ve besinsel hedeflerin keşfine yol açabilir ve RA hastaları için yenitedavi olanakları sağlayabilir. Bunun sayesinde CAM ve konvansiyonel ilaç uygulamaların RA tedavisinde entegrasyonuna yardımcı olunabilir. Sonuç olarak burada, bazı rasyonel CAM modalitelerinin, RAtedavisindeki potansiyel rolünü incelemeyi amaçladık.
Rheumatoid arthritis (RA) is one of the most prevalent_x000D_ autoimmune inflammatory joint diseases. RA affecting approximately 0.5-1.0% of the population. Current treatment-to-target strategy for RA measure disease activity scores and use conventional,_x000D_ nonsteroidal anti-inflammatory drugs (NSAIDs), and non-biological_x000D_ disease-modifying antirheumatic drugs (DMARDs) as methotrexate._x000D_ Hovewer, there is a significant proportion of patients who do not respond efficiently to some of these therapies which has been far from_x000D_ patient satisfaction. Therefore, it is apparent that novel remedies are_x000D_ urgently needed. Recently, complementary and alternative medicine_x000D_ (CAM) is extremely popular worldwide for the alleviation of RA._x000D_ Many RA patients frequently seek CAM at once in her/his life. CAM_x000D_ is usually used in addition to, and not as a substitute for conventional_x000D_ therapies. Given the poor effect of current drugs and the side effects,_x000D_ it is not at all surprising that many individuals with RA turn their face_x000D_ to CAM. Herbal medicines, dietary intervention, manuel therapy,_x000D_ calori restriction and epigenomic approach are promising in reducing_x000D_ musculoskeletal pain. This study provides a brief overview of what is_x000D_ known about CAM as a treatment for RA and will also summarize recent data for pharmacological effects of herbs including green tea,_x000D_ Tripterygium wilfordii, Curcuma longa, Veratrum grandiflorum and_x000D_ Camellia sinensis. Here we also summarise reported correlation and_x000D_ underlying molecular mechanisms among microbiome, nutriogenomics and RA. Deep understanding and clarification of the subtle mechanisms by which CAM therapies may be efficacious can be_x000D_ lead to discovering new molecular and nutritional targets in the relieving symptoms and provide new treatment opportunities for RA_x000D_ patients. This may assist the integration of CAM and conventional_x000D_ practices in the treatment of RA. Collectively, we aimed here to examine the potential role of some rationale CAM modalities in RA_x000D_ therapy.
Rheumatoid arthritis (RA) is one of the most prevalent_x000D_ autoimmune inflammatory joint diseases. RA affecting approximately 0.5-1.0% of the population. Current treatment-to-target strategy for RA measure disease activity scores and use conventional,_x000D_ nonsteroidal anti-inflammatory drugs (NSAIDs), and non-biological_x000D_ disease-modifying antirheumatic drugs (DMARDs) as methotrexate._x000D_ Hovewer, there is a significant proportion of patients who do not respond efficiently to some of these therapies which has been far from_x000D_ patient satisfaction. Therefore, it is apparent that novel remedies are_x000D_ urgently needed. Recently, complementary and alternative medicine_x000D_ (CAM) is extremely popular worldwide for the alleviation of RA._x000D_ Many RA patients frequently seek CAM at once in her/his life. CAM_x000D_ is usually used in addition to, and not as a substitute for conventional_x000D_ therapies. Given the poor effect of current drugs and the side effects,_x000D_ it is not at all surprising that many individuals with RA turn their face_x000D_ to CAM. Herbal medicines, dietary intervention, manuel therapy,_x000D_ calori restriction and epigenomic approach are promising in reducing_x000D_ musculoskeletal pain. This study provides a brief overview of what is_x000D_ known about CAM as a treatment for RA and will also summarize recent data for pharmacological effects of herbs including green tea,_x000D_ Tripterygium wilfordii, Curcuma longa, Veratrum grandiflorum and_x000D_ Camellia sinensis. Here we also summarise reported correlation and_x000D_ underlying molecular mechanisms among microbiome, nutriogenomics and RA. Deep understanding and clarification of the subtle mechanisms by which CAM therapies may be efficacious can be_x000D_ lead to discovering new molecular and nutritional targets in the relieving symptoms and provide new treatment opportunities for RA_x000D_ patients. This may assist the integration of CAM and conventional_x000D_ practices in the treatment of RA. Collectively, we aimed here to examine the potential role of some rationale CAM modalities in RA_x000D_ therapy.