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Effects of serum on in vitro susceptibility testing of echinocandins

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dc.contributor.authorsOdabasi, Zekaver; Paetznick, Victor; Rex, John H.; Ostrosky-Zeichner, Luis
dc.date.accessioned2022-03-14T08:25:07Z
dc.date.accessioned2026-01-11T10:31:32Z
dc.date.available2022-03-14T08:25:07Z
dc.date.issued2007-11
dc.description.abstractThe effects of protein binding on the activities of caspofungin, anidulafungin, and micafungin were evaluated against Candida and Aspergillus species. Adding human serum sharply increased the MICs of micafungin and anidulafungin and modestly affected the MIC of caspofungin. The increase in MICs does not appear consistent with the rate of protein binding for the three compounds.
dc.identifier.doi10.1128/AAC.01589-06
dc.identifier.issn0066-4804
dc.identifier.pubmed17785512
dc.identifier.urihttps://hdl.handle.net/11424/241747
dc.identifier.wosWOS:000250612900066
dc.language.isoeng
dc.publisherAMER SOC MICROBIOLOGY
dc.relation.ispartofANTIMICROBIAL AGENTS AND CHEMOTHERAPY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectANTIFUNGAL AGENT
dc.subjectPROTEIN-BINDING
dc.subjectASPERGILLUS-FUMIGATUS
dc.subjectMK-0991 L-743,872
dc.subjectPHARMACOKINETICS
dc.subjectTERBINAFINE
dc.subjectMICRODILUTION
dc.subjectINVITRO
dc.titleEffects of serum on in vitro susceptibility testing of echinocandins
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage4216
oaire.citation.issue11
oaire.citation.startPage4214
oaire.citation.titleANTIMICROBIAL AGENTS AND CHEMOTHERAPY
oaire.citation.volume51

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