Publication: Lack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Population
Abstract
Arka plan: IL6 geni bazı hastalık durumları ile ilişkilidir. Literatürde anevrizma oluşumu ve anevrizmal SAK ile ilişkisi çalışılmış fakat bildirilen sonuçlar kesin pozitif veya negative bilgi ile sonuçlanmamıştır. Bu çalışmada IL6 gen polimorfizmlerini bir Türk toplumunda incelemeyi ve ilişki anlayışımızı ilerletmeyi amaçladık. Sonuçlar: IL6 geninde yerleşmiş -174 G > C ve -572 G > C promotor polimorfizmlerini gruplar arası genotip farklılığı olup olmadığını incelemek için 120 intrakranyal anevrizmal SAK vakası ve 120 sağlıklı kontrolü dahil ettik. Gruplar arası farklılıklar ki-kare testi kullanılarak çalışıldı. Kontroller ile anevrizmal SAK hastaları arasında IL6 promotor 174G > C ve 572G > C polimorfizmleri için istatiksel farklılık yoktu. Netice: IL6 promotor TNPleri Türk toplumunda intrakranyal anevrizma oluşumu ve subaraknoid anevrizma patlaması ile bağlantı göstermemiştir, fakat etnik toplumlar arasındaki genetik farklılıklar farklı sonuçlar verebilir.
Background: The IL6 gene is related to several disease states. Its relation to aneurysm formation and aneurysmal SAH has been studied in the literature, but the reported results have not resulted in definite positive or negative data. In this study we aimed to examine IL6 gene polymorphisms in a Turkish population and further our understanding of the relationship. Results: We included 120 intracranial aneurysm SAH cases and 120 healthy controls to examine whether there was a genotype difference between these groups in the -174 G > C and -572 G > C promoter polymorphisms located in the IL6 gene. The differences between groups were studied using a chi-squared test. There was no statistical difference between aneurysmal SAH patients and controls for IL6 promoter 174G > C and 572G > C polymorphisms. Conclusions: IL6 promoter SNPs did not show a correlation with intracranial aneurysm formation and subarachnoid aneurysmal rupture in a Turkish population, but genetic differences between ethnic populations may give different results.
Background: The IL6 gene is related to several disease states. Its relation to aneurysm formation and aneurysmal SAH has been studied in the literature, but the reported results have not resulted in definite positive or negative data. In this study we aimed to examine IL6 gene polymorphisms in a Turkish population and further our understanding of the relationship. Results: We included 120 intracranial aneurysm SAH cases and 120 healthy controls to examine whether there was a genotype difference between these groups in the -174 G > C and -572 G > C promoter polymorphisms located in the IL6 gene. The differences between groups were studied using a chi-squared test. There was no statistical difference between aneurysmal SAH patients and controls for IL6 promoter 174G > C and 572G > C polymorphisms. Conclusions: IL6 promoter SNPs did not show a correlation with intracranial aneurysm formation and subarachnoid aneurysmal rupture in a Turkish population, but genetic differences between ethnic populations may give different results.