Publication:
Expression of NM23 and tenascin in invasive ductal carcinomas of the breast

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dc.contributor.authorsKaya, H.; Hücümenoğlu, S.; Bozkurt, S. U.; Ekicioğlu, G.; Kotiloğlu, E.
dc.date.accessioned2022-03-28T12:45:32Z
dc.date.accessioned2026-01-10T17:17:29Z
dc.date.available2022-03-28T12:45:32Z
dc.date.issued2002
dc.description.abstractOBJECTIVE: In this series of ductal carcinoma of the breast, immunoexpression of antimetastasis gene nm23 and tenascin was examined and the role in prognosis was investigated by correlation with the tumour grade and stage, and ER/PR immunoexpression. MATERIAL AND METHODS: In this study 27 ductal carcinomas of the breast were analysed for expression of tenascin and nm23 antimetastasis genes by immunohistochemistry. RESULTS: The results of our study revealed a statistically significant correlation between nm23-H1 immunoexpression and lymph node metastasis. We also found a statistically significant correlation between tenascin and nm23-H1 immunoexpression. Our results suggest that tenascin limits tumour spread. CONCLUSION(S): Antimetastasis gene expression can be used in predicting lymph node metastasis in ductal carcinomas of the breast.
dc.identifier.issn0392-2936
dc.identifier.pubmedPMID: 12094967
dc.identifier.urihttps://hdl.handle.net/11424/254898
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Gynaecological Oncology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdult
dc.subjectFemale
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectPrognosis
dc.subjectBiomarkers, Tumor
dc.subjectAged
dc.subjectImmunohistochemistry
dc.subjectLymphatic Metastasis
dc.subjectTranscription Factors
dc.subjectNeoplasm Staging
dc.subjectTenascin
dc.subjectBreast Neoplasms
dc.subjectCarcinoma, Ductal, Breast
dc.subjectMonomeric GTP-Binding Proteins
dc.subjectNM23 Nucleoside Diphosphate Kinases
dc.subjectNucleoside-Diphosphate Kinase
dc.titleExpression of NM23 and tenascin in invasive ductal carcinomas of the breast
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage263
oaire.citation.startPage261
oaire.citation.titleEuropean Journal of Gynaecological Oncology
oaire.citation.volume3

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