Publication:
Antinociceptive effect of D-aspartic acid in mice

Simple item page
dc.contributor.authorsOnat, F.; Toker, F.; Aslan, N.; Oktay, S.; Berkman, K.
dc.date.accessioned2022-03-15T11:12:25Z
dc.date.accessioned2026-01-11T17:21:47Z
dc.date.available2022-03-15T11:12:25Z
dc.date.issued1995
dc.description.abstractThe effects of D- and L-aspartic acids on the nociceptive tail flick reflex in mice were investigated. D-Aspartic acid (115-230 mg/kg, IP) was found to increase tail flick latency significantly. Naloxone (0.1 mg/kg) abolished the analgesic effect of D-aspartic acid (115 mg/kg). Morphine and D-aspartic acid, when combined at their nonanalgesic doses, led to significant analgesia. It may be concluded that the opioid system is involved in the antinociceptive effect of D-aspartic acid. Both morphine and D-aspartic acid were previously reported to inhibit L-aspartic acid production via blockade of L-asparaginase. L-Aspartic acid, which was ineffective alone, significantly inhibited the antinociceptive effects of both D-aspartic acid and morphine.
dc.identifier.doi10.1016/0091-3057(95)00016-p
dc.identifier.issn0091-3057
dc.identifier.pubmedPMID: 7675849
dc.identifier.urihttps://hdl.handle.net/11424/249072
dc.language.isoeng
dc.relation.ispartofPharmacology, Biochemistry, and Behavior
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFemale
dc.subjectAnimals
dc.subjectMale
dc.subjectAnalgesics
dc.subjectTime Factors
dc.subjectDose-Response Relationship, Drug
dc.subjectAspartic Acid
dc.subjectPain Measurement
dc.subjectMice
dc.subjectMice, Inbred BALB C
dc.subjectNaloxone
dc.subjectMorphine
dc.titleAntinociceptive effect of D-aspartic acid in mice
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage719
oaire.citation.startPage715
oaire.citation.titlePharmacology, Biochemistry, and Behavior
oaire.citation.volume4

Files

Collections

Araştırma Çıktıları