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Diterpenes from the berries of Juniperus excelsa

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dc.contributor.authorsTopcu, G; Erenler, R; Cakmak, O; Johansson, CB; Celik, C; Chai, HB; Pezzuto, JM
dc.date.accessioned2022-03-12T17:16:16Z
dc.date.accessioned2026-01-11T10:51:23Z
dc.date.available2022-03-12T17:16:16Z
dc.date.issued1999
dc.description.abstractFrom the hexane extract of berries of Juniperus excelsa, one new and four known diterpenes were isolated besides a known sesquiterpene. The structures of the known diterpenes were identified as isopimaric, isocommunic, (-)ent-trans communic and sandracopimaric acids, along with the sesquiterpene 4a-hydroxycedrol and the new compound which was elucidated as 3 alpha-acetoxylabda-8(17), 13(16), 14-trien-19-oic acid (juniperexcelsic acid). Cytotoxic activity of the hexane extract was investigated against a panel of cell line and found highyl active against LNCaP, KB-V (+VLB) and KB-V (-VLB) cell lines. Furthermore, the hexane and methanol extracts, and the new compound were found to be moderately active against Mycobacterium tuberculosis. (C) 1999 Elsevier Science Ltd. All rights reserved.
dc.identifier.doi10.1016/S0031-9422(98)00675-X
dc.identifier.issn0031-9422
dc.identifier.pubmed10234860
dc.identifier.urihttps://hdl.handle.net/11424/227491
dc.identifier.wosWOS:000080012000016
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofPHYTOCHEMISTRY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectJuniperus excelsa
dc.subjectCupressaceae
dc.subjectberries
dc.subjectditerpenes
dc.subjectjuniperexcelsic acid
dc.subjectsesquiterpene
dc.subjectcytotoxic
dc.subjectantituberculosis and antibacterial activity
dc.titleDiterpenes from the berries of Juniperus excelsa
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage1199
oaire.citation.issue7
oaire.citation.startPage1195
oaire.citation.titlePHYTOCHEMISTRY
oaire.citation.volume50

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