A randomized, double-blind comparison of nadifloxacin 1% cream alone and with benzoyl peroxide 5% lotion in the treatment of mild to moderate facial acne vulgaris

Abstract

Amaç: Hafif-orta şiddetli akne vulgaris tedavisinde nadifloksasin kremin tek başına veya benzoil peroksit ile birlikte kullanımının etkinliğini karşılaştırma. Hastalar ve Yöntem: Çift kör, randomize çalışma, toplam 93 hasta 2 grup olarak ya nadifloksasin kremi ya benzoil peroksit losyonun baz formu ya da benzoil peroksit ile birlikte 8 hafta süre ile kullandı. Bulgular: İnflamatuar lezyonlar tek başına nadifloksasin kullanan grupta(n=46) %22, 08, nadifloksasin+benzoil peroksit kullanan grupta(n=47) %53,5 oranında azaldı. Tek başına nadifloksasin kullanan grupta beş (%10,9), nadifloksasin+benzoil peroksit kullanan grupta 18(%38,3)hastada inflamatuar lezyonlarda %50 ve üzeri azalma görüldü. Sonuç: Her iki tedavi de istatistiksel olarak etkili bulundu ancak nadifloksasin+benzoil peroksit grubunda belirgin olarak inflamatuar lezyonlarda azalma görüldü. Her iki tedavi de hafif yan etkiler ile çok iyi tolere edildi.

Objective: To compare the efficacy of nadifloxacin alone and with benzoyl peroxide in the treatment of mild to moderate facial acne vulgaris. Patients and Methods: This double-blind, randomized study was conducted in a total of 93 acne patients, with at least 10 inflammatory lesions, but no more than 3 nodules or cysts on the face. All patients were instructed to apply nadifloxacin 1% cream twice daily and randomized to apply either benzoyl peroxide 5% lotion or its vehicle once daily for 8 weeks. Results: The mean percent reduction in inflammatory lesions were 22.08% in the nadifloxacin group (n=46) and 53.5% in the nadifloxacin+benzoyl peroxide group (n=47). Five (10.9%) patients in the nadifloxacin group and 18 (38.3%) patients in the nadifloxacin+benzoyl peroxide group achieved a 50% and greater reduction in the inflammatory lesion count. Conclusion: Both treatment regimens were statistically effective, but a significantly greater reduction of the inflammatory lesions was seen in the nadifloxacin+benzoyl peroxide group. The number of patients who achieved a 50% and greater reduction in inflammatory lesion count was significantly higher in the nadifloxacin+benzoyl peroxide group. Both treatment regimens were well tolerated with mild side effects.