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Synthesis of new 2,5-disubstituted-1,3,4-thiadiazoles and preliminary evaluation of anticonvulsant and antimicrobial activities

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dc.contributor.authorsDogan, HN; Duran, A; Rollas, S; Sener, G; Uysal, MK; Gulen, D
dc.date.accessioned2022-03-12T16:58:05Z
dc.date.accessioned2026-01-11T13:14:24Z
dc.date.available2022-03-12T16:58:05Z
dc.date.issued2002
dc.description.abstractTwo new series of 2.5-disubstituted-1,3.4-thiadiazoles were synthesized for their possible anticonvulsant. antibacterial and antifungal activities. The degree of protection afforded by these compounds at a dose of 100 mg/kg ip against pentylene-tetrazole-induced convulsions in mice ranged from 0 to 90%, Among these compounds, 2a (90%) and 2g (70%) showed maximum protection. Antimicrobial tests showed that the MIC value of 3j against Pseudomanas aeruginosa was equal to that of penicillin. (C) 2002 Elsevier Science Ltd. All rights reserved.
dc.identifier.doi10.1016/S0968-0896(02)00143-8
dc.identifier.issn0968-0896
dc.identifier.pubmed12110309
dc.identifier.urihttps://hdl.handle.net/11424/227008
dc.identifier.wosWOS:000177484800008
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofBIOORGANIC & MEDICINAL CHEMISTRY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSTRUCTURE ELUCIDATION
dc.subjectDERIVATIVES
dc.subject1,3,4-THIADIAZOLE
dc.subjectTHIADIAZOLES
dc.subjectTRIAZOLES
dc.titleSynthesis of new 2,5-disubstituted-1,3,4-thiadiazoles and preliminary evaluation of anticonvulsant and antimicrobial activities
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage2898
oaire.citation.issue9
oaire.citation.startPage2893
oaire.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY
oaire.citation.volume10

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