Publication:
Synthesis of new 2,5-disubstituted-1,3,4-thiadiazoles and preliminary evaluation of anticonvulsant and antimicrobial activities

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dc.contributor.authorŞENER, GÖKSEL
dc.contributor.authorsDogan, Hatice N.; Duran, Arzu; Rollas, Sevim; Sener, Göksel; Uysal, Meral K.; Gülen, Dumrul
dc.date.accessioned2022-03-15T11:22:08Z
dc.date.accessioned2026-01-10T17:36:07Z
dc.date.available2022-03-15T11:22:08Z
dc.date.issued2002
dc.description.abstractTwo new series of 2,5-disubstituted-1,3,4-thiadiazoles were synthesized for their possible anticonvulsant, antibacterial and antifungal activities. The degree of protection afforded by these compounds at a dose of 100mg/kg i.p. against pentylenetetrazole-induced convulsions in mice ranged from 0 to 90%. Among these compounds, 2a (90%) and 2g (70%) showed maximum protection. Antimicrobial tests showed that the MIC value of 3j against Pseudomanas aeruginosa was equal to that of penicillin.
dc.identifier.doi10.1016/s0968-0896(02)00143-8
dc.identifier.issn0968-0896
dc.identifier.pubmedPMID: 12110309
dc.identifier.urihttps://hdl.handle.net/11424/249677
dc.language.isoeng
dc.relation.ispartofBioorganic & Medicinal Chemistry
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnimals
dc.subjectPseudomonas aeruginosa
dc.subjectDrug Evaluation, Preclinical
dc.subjectAnti-Bacterial Agents
dc.subjectMicrobial Sensitivity Tests
dc.subjectMice
dc.subjectMice, Inbred BALB C
dc.subjectAnticonvulsants
dc.subjectThiadiazoles
dc.subjectSeizures
dc.titleSynthesis of new 2,5-disubstituted-1,3,4-thiadiazoles and preliminary evaluation of anticonvulsant and antimicrobial activities
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage2898
oaire.citation.startPage2893
oaire.citation.titleBioorganic & Medicinal Chemistry
oaire.citation.volume9

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