Publication:
Reduction of Amphotericin B-Induced Renal Tubular Apoptosis by N-Acetylcysteine

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dc.contributor.authorsOdabasi, Z.; Karaalp, A.; Cermik, H.; Mohr, J.; Tigen, E. T.; Koc, M.; Korten, V.
dc.date.accessioned2022-03-14T10:02:18Z
dc.date.accessioned2026-01-10T18:12:55Z
dc.date.available2022-03-14T10:02:18Z
dc.date.issued2009-07
dc.description.abstractThe reduction of amphotericin B (AmB)-induced renal tubular apoptosis and nephrotoxicity by N-acetylcysteine (NAC) in a murine model was evaluated. Four groups of rats were treated with AmB for 5 days, and each group concomitantly received two doses of 30, 60, or 120 mg of NAC/kg of body weight/day or sterile water for 5 days. Groups that received concomitant NAC at any dose had significantly decreased levels of apoptosis compared to that in animals receiving AmB only (48.8% versus 27.4, 23.6, or 23.5%, respectively; P < 0.001).
dc.identifier.doi10.1128/AAC.00001-09
dc.identifier.eissn1098-6596
dc.identifier.issn0066-4804
dc.identifier.pubmed19414577
dc.identifier.urihttps://hdl.handle.net/11424/243932
dc.identifier.wosWOS:000267354000057
dc.language.isoeng
dc.publisherAMER SOC MICROBIOLOGY
dc.relation.ispartofANTIMICROBIAL AGENTS AND CHEMOTHERAPY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLIPID FORMULATIONS
dc.subjectNEPHROTOXICITY
dc.subjectDEOXYCHOLATE
dc.subjectTOXICITY
dc.subjectNEPHROPATHY
dc.subjectPREVENTION
dc.subject5-PERCENT
dc.subjectTOLERANCE
dc.subjectEMULSION
dc.subjectDEXTROSE
dc.titleReduction of Amphotericin B-Induced Renal Tubular Apoptosis by N-Acetylcysteine
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage3102
oaire.citation.issue7
oaire.citation.startPage3100
oaire.citation.titleANTIMICROBIAL AGENTS AND CHEMOTHERAPY
oaire.citation.volume53

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