Publication:
Effect of imipenem on serum bactericidal activity of normal and splenectomized rats [IMIPENEMIN NORMAL VE SPLENEKTOMILI SICANLARDA SERUMUN BAKTERISIDAL AKTIVITESINE ETKISI]

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dc.contributor.authorsSoyletir G., Esiturk A., Demirel M., Duman N., Johansson C.B.
dc.date.accessioned2022-03-28T14:50:03Z
dc.date.accessioned2026-01-11T08:47:07Z
dc.date.available2022-03-28T14:50:03Z
dc.date.issued1995
dc.description.abstractIn order to investigate bactericidal activity of sera obtained from sham operated and splenectomized rats; experimental pneumonia was constituted by inoculating 3 x 108 cfu/ml (7 x LD50) suspension of Pseudomonas aeruginosa intranasally 12 weeks after inoculation. IgM levels, serum bactericidal activity (SBA) and contribution of imipenem to this activity was determined in sera collected before and 12 days after inoculation. Test strain which was found to be resistant initially converted to be susceptible to the sera of sham operated rats obtained after infection with or without aid of antimicrobial. However sera collected from splenectomized rats after infection showed SBA in the presence of imipenem only. In conclusion; to reduce high mortality rate of Pseudomonas sepsis in splenectomized patients one can benefit this effect of imipenem on SBA.
dc.identifier.issn3749096
dc.identifier.urihttps://hdl.handle.net/11424/255297
dc.language.isotur
dc.relation.ispartofMikrobiyoloji Bulteni
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectImipenem
dc.subjectSerum bactericidal activity
dc.titleEffect of imipenem on serum bactericidal activity of normal and splenectomized rats [IMIPENEMIN NORMAL VE SPLENEKTOMILI SICANLARDA SERUMUN BAKTERISIDAL AKTIVITESINE ETKISI]
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage232
oaire.citation.issue3
oaire.citation.startPage227
oaire.citation.titleMikrobiyoloji Bulteni
oaire.citation.volume29

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