Publication:
Relationship of PPARG overexpression with prognostic parameters in papillary thyroid carcinoma

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dc.contributor.authorASYA, ORHAN
dc.contributor.authorYUMUŞAKHUYLU, ALİ CEMAL
dc.contributor.authorBAĞCI ÇULÇİ, PELİN
dc.contributor.authorŞAHİN, AKIN
dc.contributor.authorOYSU, ÇAĞATAY
dc.contributor.authorKAYA, HANDAN
dc.contributor.authorsASYA O., YUMUŞAKHUYLU A. C., BAĞCI ÇULÇİ P., KAYA H., Gonen A., Gundogdu Y., Muradov T., ŞAHİN A., OYSU Ç.
dc.date.accessioned2023-03-27T09:57:45Z
dc.date.accessioned2026-01-11T10:24:51Z
dc.date.available2023-03-27T09:57:45Z
dc.date.issued2022-02-01
dc.description.abstractObjectives. PAX8/PPARG chromosomal rearrangement is frequently seen in thyroid cancer, and PPARG overexpression has been shown in the follicular variant of papillary thyroid carcinoma, but not in papillary thyroid carcinoma other than the follicular variant. The main aim of this study was to investigate the frequency of PPARG overexpression among papillary thyroid carcinoma and if there were any variants of papillary thyroid carcinoma with PPARG overexpression other than the follicular variant. Methods. Immunohistochemical analysis of PPARG overexpression was performed using a PPARG monoclonal antibody in a series of 111 paraffin-embedded blocks of thyroid tumours. Of the patients in our study, 100 were diagnosed with papillary thyroid carcinoma, 9 with follicular adenoma and 2 with follicular carcinoma. Results. PPARG staining was detected in 19 of the 111 cases. Sixteen patients with PPARG overexpression had papillary thyroid carcinoma and 3 had follicular adenoma. Conclusion. PPARG overexpression was detected mainly in follicular-variant papillary thyroid carcinoma. Vascular invasion, lymphatic invasion, thyroid capsule invasion and lymph node positivity were lower in patients with PPARG overexpression.
dc.identifier.citationASYA O., YUMUŞAKHUYLU A. C., BAĞCI ÇULÇİ P., KAYA H., Gonen A., Gundogdu Y., Muradov T., ŞAHİN A., OYSU Ç., "Relationship of PPARG overexpression with prognostic parameters in papillary thyroid carcinoma", ACTA OTORHINOLARYNGOLOGICA ITALICA, cilt.42, sa.1, ss.34-40, 2022
dc.identifier.doi10.14639/0392-100x-n1034
dc.identifier.endpage40
dc.identifier.issn0392-100X
dc.identifier.issue1
dc.identifier.startpage34
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/648e56b9-c21c-45cd-8410-e6be14d5a1f5/file
dc.identifier.urihttps://hdl.handle.net/11424/287882
dc.identifier.volume42
dc.language.isoeng
dc.relation.ispartofACTA OTORHINOLARYNGOLOGICA ITALICA
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectCerrahi Tıp Bilimleri
dc.subjectKulak Burun Boğaz
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectSurgery Medicine Sciences
dc.subjectOtolaryngology
dc.subjectKULAK BURUN BOĞAZ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectOTORHINOLARYNGOLOGY
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectOtorhinolaryngology
dc.subjectSpeech and Hearing
dc.subjectpapillary thyroid carcinoma
dc.subjectPPARG overexpression
dc.subjectprognostic parameters
dc.subjectFOLLICULAR VARIANT
dc.subjectFUSION PROTEIN
dc.subjectCANCER
dc.subjectTHERAPY
dc.subjectCONTROVERSIES
dc.subjectMANAGEMENT
dc.subjectEXPRESSION
dc.subjectpapillary thyroid carcinoma
dc.subjectPPARG overexpression
dc.subjectprognostic parameters
dc.subjectPAX8/PPARG fusion protein (PPFP)
dc.subjectpioglitazone
dc.titleRelationship of PPARG overexpression with prognostic parameters in papillary thyroid carcinoma
dc.typearticle
dspace.entity.typePublication

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