Self-healing and cell adhesion properties of dynamic and photo-crosslinking PEG-based dual networks soft hydrogels

Abstract

Self-healing involves an autonomic response that repairs damage to living systems. In this study, polyethylene glycol (PEG) underwent aldehyde-functionalization using the Albrigh Goldman oxidation technique. Flexible, dynamic crosslink points to encourage self-healing are generated by the formation of acylhydrazone bonds formed between long-chain PEG dialdehyde and adipic acid dihydrazide. Furthermore, methacrylated PEG was synthesized to support the polymer matrix through dynamic covalent bonds. The hydrogels exhibited self-healing within the first 4 hours at room temperature and after 24 h. hydrogels with mechanical performance close to the original were obtained. They have good tensile and elongation strength and are well-suited for interaction with living cells.