Publication: PREEKLAMPSİDE PLASENTAL APOPTOZİS
Abstract
Amaç: Preeklampsi ile komplike olmuş gebeliklerde plasental örneklerde trofoblast apoptozisinin araştırılması Gereç ve yöntemler: Bu çalışma da 28 preeklampsi hastası ile 10 sağlıklı term tekil gebeden olmak üzere toplam 38 plasental örnekte trofoblastlarda TUNEL metodu ve elektron mikroskopisi ile apoptozis araştırılmıştır. Sonuç: Her iki grup yaş ve parite açısından farklılık göstermezken, kontrol grubuna ortalama gebelik haftası preeklamptik grupta anlamlı daha düşük (33.2(3.2 vs. 39.1(0.5 p<0.0001), buna karşın trofoblastlarda apoptotik indeks anlamlı oranda daha yüksek bulunmuştur (40.7(17.9 vs. 25.2(10.6, p<0.05). Değerlendirme: Bu sonuçlar preeklampsi ile komplike olmuş gebeliklerde trofoblastlarda apoptozisde bir artış olduğunu ve bu artışın plasental yaşlanma ile gelişen apoptozisden farklı olduğu görüşünü desteklemektedir.
Objective: We aimed in this study to determine if trophoblastic apoptosis is increased in placentas from preeclamptic women compared to healthy term control placentas. Patients and methods: 28 preeclamptic and 10 healthy control placentas were used for the study. Apoptosis in the trophoblasts were analyzed using TUNEL method and electron microscopy techniques. Results: Both groups were comparable in terms of age and parity. However, mean gestational week was significantly lower (33.2(3.2 vs. 39.1(0.5 p<0.0001, respectively), and apoptotic rate in the trophoblasts were significantly higher (40.7(17.9 vs. 25.2(10.6, p<0.05, respectively) in the preeclamptic group compared to controls. Conclusion: These results suggest that trophoblast apoptosis is increased in the preeclamptic placentas and that this form of apoptosis is different from that occurring with placental aging as a consequence of cell turnover.
Objective: We aimed in this study to determine if trophoblastic apoptosis is increased in placentas from preeclamptic women compared to healthy term control placentas. Patients and methods: 28 preeclamptic and 10 healthy control placentas were used for the study. Apoptosis in the trophoblasts were analyzed using TUNEL method and electron microscopy techniques. Results: Both groups were comparable in terms of age and parity. However, mean gestational week was significantly lower (33.2(3.2 vs. 39.1(0.5 p<0.0001, respectively), and apoptotic rate in the trophoblasts were significantly higher (40.7(17.9 vs. 25.2(10.6, p<0.05, respectively) in the preeclamptic group compared to controls. Conclusion: These results suggest that trophoblast apoptosis is increased in the preeclamptic placentas and that this form of apoptosis is different from that occurring with placental aging as a consequence of cell turnover.