Publication: Defibrotide augments the anticandidial activity of NK cells
| dc.contributor.authors | Turhan, A; Piskin, AK; Emerk, K; Imir, T | |
| dc.date.accessioned | 2022-03-12T16:57:27Z | |
| dc.date.accessioned | 2026-01-11T06:45:35Z | |
| dc.date.available | 2022-03-12T16:57:27Z | |
| dc.date.issued | 1997 | |
| dc.description.abstract | 1. The mechanism of action of Defibrotide, a fibrinolytic agent on Natural Killer (NK) cell cytotoxicity, was investigated through verapamil, TMB-8 cells and pertussis toxin. 2. Defibrotide increased the activity against Candida albicans cells (anticandidial activity), and it is determined that the calcium channels have a role in this effect. 3. Blockage of calcium channels reduced the anticandidial effect by 39.2%. Pertussis toxin led to a 10.7% inhibition, whereas the application of TMB-8 resulted in the stimulation of anticandidial activity. 4. It is concluded that defibrotide is a potent activator of NK cells. (C) 1997 Elsevier Science Inc. | |
| dc.identifier.doi | 10.1016/S0306-3623(96)00311-4 | |
| dc.identifier.issn | 0306-3623 | |
| dc.identifier.pubmed | 9184811 | |
| dc.identifier.uri | https://hdl.handle.net/11424/226940 | |
| dc.identifier.wos | WOS:A1997WZ41700018 | |
| dc.language.iso | eng | |
| dc.publisher | ELSEVIER SCIENCE INC | |
| dc.relation.ispartof | GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | NATURAL-KILLER-CELLS | |
| dc.subject | INVIVO | |
| dc.subject | MARROW | |
| dc.title | Defibrotide augments the anticandidial activity of NK cells | |
| dc.type | article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 735 | |
| oaire.citation.issue | 5 | |
| oaire.citation.startPage | 733 | |
| oaire.citation.title | GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | |
| oaire.citation.volume | 28 |