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Condensed 1,4-dihydropyridines with various esters and their calcium channel antagonist activities

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dc.contributor.authorsBulbul, Bahadir; Ozturk, Gokce Sevim; Vural, Mert; Simsek, Rahime; Sarioglu, Yusuf; Linden, Anthony; Ulgen, Mert; Safak, Cihat
dc.date.accessioned2022-03-12T17:46:57Z
dc.date.accessioned2026-01-10T17:25:42Z
dc.date.available2022-03-12T17:46:57Z
dc.date.issued2009
dc.description.abstractNew alkyl 2,6,6-(2,7,7)-trimethyl-4-(2-fluoro-3-chloro-5-trifluoromethylphenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates and 9-(3-chloro-2-fluoro-5-trifluoromethylphenyl)-6,6(7,7)-dimethyl-6,7-dihydrofuro[3,4-b]quinoline-1,8-diones have been synthesised and their calcium antagonistic activities on isolated rabbit sigmoid colon have been investigated and compared with Nifedipine. The investigation examined the influence of ester groups in the 3-position of the HHQ ring and the 2-methoxyethyl analogs were found to be the most active derivatives. (C) 2008 Elsevier Masson SAS. All rights reserved.
dc.identifier.doi10.1016/j.ejmech.2008.10.008
dc.identifier.eissn1768-3254
dc.identifier.issn0223-5234
dc.identifier.pubmed19013690
dc.identifier.urihttps://hdl.handle.net/11424/229619
dc.identifier.wosWOS:000265339900029
dc.language.isoeng
dc.publisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
dc.relation.ispartofEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHexahydroquinoline
dc.subjectFuroquinoline
dc.subjectCalcium antagonistic activity
dc.subjectBiotransformation
dc.subjectNITRIC-OXIDE
dc.subjectSMOOTH-MUSCLE
dc.subjectPHARMACOLOGICAL-ACTIVITIES
dc.subjectIN-VITRO
dc.subjectDERIVATIVES
dc.subjectHEXAHYDROQUINOLINONES
dc.subjectMODULATORS
dc.subjectCELLS
dc.titleCondensed 1,4-dihydropyridines with various esters and their calcium channel antagonist activities
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage2058
oaire.citation.issue5
oaire.citation.startPage2052
oaire.citation.titleEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
oaire.citation.volume44

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