Publication: Anticancer drug release from poly(N-isopropylacrylamide/itaconic acid) copolymeric hydrogels
| dc.contributor.author | KAYAMAN APOHAN, NİLHAN | |
| dc.contributor.authors | Tasdelen, B; Kayaman-Apohan, N; Guven, O; Baysal, BM | |
| dc.date.accessioned | 2022-03-12T17:22:57Z | |
| dc.date.accessioned | 2026-01-11T10:27:04Z | |
| dc.date.available | 2022-03-12T17:22:57Z | |
| dc.date.issued | 2005 | |
| dc.description.abstract | The drug uptake and release of anticancer drug from N-isopropylacrylamide/itaconic acid copolymeric hydrogels containing 0-3 mol% of itaconic acid irradiated at 48 kGy have been investigated. 5-Fluorouracil (5-FU) is used as a model anticancer drug. The effect of 5-FU solution on swelling characteristics of PNIPAArn and P(NIPAAm/IA) copolymeric hydrogels have also been studied. The percent swelling, equilibrium swelling, equilibrium water/5-FU content and diffusion constant values are evaluated for poly(N-isopropylacrylamide) (PNIPAAm) and poly(N-isopropylacrylamide/itaconic) (P(NIPAAm/IA)) hydrogels at 130 ppm of 5-FU solution at room temperature. Diffusion of 5-FU solution into the hydrogels has been found to be the non-Fickian type. Finally, the kinetics of drug release from the hydrogels are examined. (c) 2004 Elsevier Ltd. All rights reserved. | |
| dc.identifier.doi | 10.1016/j.radphyschem.2004.09.028 | |
| dc.identifier.issn | 0969-806X | |
| dc.identifier.uri | https://hdl.handle.net/11424/228460 | |
| dc.identifier.wos | WOS:000230741900005 | |
| dc.language.iso | eng | |
| dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | |
| dc.relation.ispartof | RADIATION PHYSICS AND CHEMISTRY | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | hydrogel | |
| dc.subject | N-isopropylacrylamide | |
| dc.subject | itaconic acid | |
| dc.subject | 5-fluorouracil | |
| dc.subject | drug release | |
| dc.subject | DIFFUSION | |
| dc.subject | WATER | |
| dc.title | Anticancer drug release from poly(N-isopropylacrylamide/itaconic acid) copolymeric hydrogels | |
| dc.type | article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 345 | |
| oaire.citation.issue | 6 | |
| oaire.citation.startPage | 340 | |
| oaire.citation.title | RADIATION PHYSICS AND CHEMISTRY | |
| oaire.citation.volume | 73 |