PREPARATION AND EVALUATION OF CROSS-LINKED CHITOSAN MICROSPHERES CONTAINING FUROSEMIDE

Abstract

Chitosan microspheres containing furosemide were prepared from a w/o emulsion system using liquid paraffin as the external phase and a solution of chitosan in acetic acid as the disperse phase. Discrete spherical furosemide microspheres having a 350-690 mu m diameter range were produced. Microsphere properties were affected by the preparation variables such as the type and concentration of chitosan, drug concentration, cross-linking process, the viscosity of oil and stirring rate during the preparation. The results were examined kinetically. Dissolution data indicated that the release followed the Higuchi matrix model.