Publication: Tetra vs. octa-How it affects the photophysical, photochemical, physicochemical and biological properties of mercaptophenol-substituted Zn phthalocyanines
Abstract
Zn phthalocyanines tetra- and octa- substituted in peripheral positions by mercaptophenol moieties were prepared. Photophysical, photochemical, physicochemical and biological properties relevant from a photodynamic therapy point of view have been determined, showing that the tetra-substituted derivatives have better potential, confirmed by in vitro tests performed on MCF-7 cells that induced significant cell death without showing dark toxicity.
Description
Keywords
Kimya, Biyokimya, Alkoloidler, Temel Bilimler, Chemistry, Biochemistry, Alcaloides, Natural Sciences, KİMYA, MULTİDİSİPLİNER, Temel Bilimler (SCI), CHEMISTRY, MULTIDISCIPLINARY, CHEMISTRY, Natural Sciences (SCI), Kimya (çeşitli), Genel Kimya, Fizik Bilimleri, Chemistry (miscellaneous), General Chemistry, Physical Sciences, Phthalocyanine, mercaptophenol, singlet oxygen generation, photodynamic therapy, in vitro, PHOTODYNAMIC THERAPY, PERIPHERAL SUBSTITUTION, ZINC PHTHALOCYANINE, PHOTOSENSITIZERS
Citation
TOPKAYA TAŞKIRAN D., Aydin D., Ben Aziza H., ŞAHİN Z., İŞCİ Ü., Durand D., TAZEBAY U. H. , Gary-Bobo M., DUMOULIN F., "Tetra vs. octa-How it affects the photophysical, photochemical, physicochemical and biological properties of mercaptophenol-substituted Zn phthalocyanines", JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 2022