Conductive polymeric film loaded with ibuprofen as a wound dressing material

Abstract

In current study, sodium alginate/gelatin/hyaluronic acid/reduced graphene oxide (SAIg/Gel/HA/RGO) electroconductive composite polymeric films were fabricated for wound dressing applications. In the production of composite film, while SAIg/Gel/HA was used as a polymeric network, RGO (0, 10, 20% v/v) was employed as an electroactive material. Produced films were characterized by FT-IR, XRD and SEM analyses. In order to observe potential usage of desired material as a wound dressing, electroconductive and mechanical performances, swelling behavior, water vapor transmission rate (WVTR), oxygen permeability and cytotoxicity of the films were investigated by concerned test method. To improve the healing effect of the films and reduce pain in the wound, they were loaded with ibuprofen, which is an anti-inflammatory drug. The drug release evaluations showed that SAIg/Gel/HA/RGO films were more effective than pure films for controlled release of the model drug. All results suggested that SAIg/Gel/HA/RGO electroconductive polymeric films have a great potential for wound dressing material in the future applications.