Publication: COVID-19-related mortality in kidney transplant and dialysis patients: results of the ERACODA collaboration
| dc.contributor.authors | Hilbrands, Luuk B; Duivenvoorden, Raphaël; Vart, Priya; Franssen, Casper F M; Hemmelder, Marc H; Jager, Kitty J; Kieneker, Lyanne M; Noordzij, Marlies; Pena, Michelle J; Vries, Hanne de; Arroyo, David; Covic, Adrian; Crespo, Marta; Goffin, Eric; Islam, Mahmud; Massy, Ziad A; Montero, Nuria; Oliveira, João P; Roca Muñoz, Ana; Sanchez, J Emilio; Sridharan, Sivakumar; Winzeler, Rebecca; Gansevoort, Ron T; ERACODA Collaborators; van der Net, Jeroen B; Essig, Marie; du Buf-Vereijken, Peggy W G; van Ginneken, Betty; Maas, Nanda; Vogt, Liffert; van Jaarsveld, Birgit C; Bemelman, Frederike J; Klingenberg-Salahova, Farah; Heenan-Vos, Frederiek; Vervloet, Marc G; Nurmohamed, Azam; Abramowicz, Daniel; Verhofstede, Sabine; Maoujoud, Omar; Fialova, Jana; Melilli, Edoardo; Favà, Alex; Cruzado, Josep M; Lips, Joy; Hengst, Maaike; Gellert, Ryszard; Rydzewski, Andrzej; Alferes, Daniela G; Rychlik, Ivan; Zakharova, Elena V; Ambuehl, Patrice Max; Lepeytre, Fanny; Rabaté, Clémentine; Rostoker, Guy; Marques, Sofia; Azasevac, Tijana; Katicic, Dajana; Dam, Marc ten; Krüger, Thilo; Logtenberg, Susan J J; Fricke, Lutz; van Zanen, A L; Slebe, Jeroen J P; Kemlin, Delphine; van de Wetering, Jacqueline; Eiselt, Jaromir; Kielberger, Lukas; El-Wakil, Hala S; ElHafeez, Samar Abd; Canal, Christina; Facundo, Carme; Ramos, Ana M; Debska-Slizien, Alicja; Veldhuizen, Nicoline M H; Panagoutsos, Stylianos; Matceac, Irina; Nistor, Ionut; Cordos, Monica; Groeneveld, J H M; van Buren, Marjolijn; Diekmann, Fritz; Ferreira, Ana C; Santos, Augusto Cesar S; Arias-Cabrales, Carlos; Llinàs-Mallol, Laura; Buxeda, Anna; Tàrrega, Carla Burballa; Redondo-Pachon, Dolores; Jimenez, Maria Dolores Arenas; Hofstra, Julia M; Franco, Antonio; Rodríguez-Ferrero, María L; Manzanos, Sagrario Balda; de Arriba, Gabriel; Haridian Sosa Barrios, R; Bartelet, Karlijn; Demir, Erol; Hollander, Daan A M J; Kerckhoffs, Angele; Büttner, Stefan; de Vries, Aiko P.J; Meziyerh, Soufian; van der Helm, Danny; Reinders, Marlies; Bouwsma, Hanneke; Petruliene, Kristina; Maloney, Sharon; Verberk, Iris; Di Luca, Marina; Tuğlular, Serhan Z; Beerenhout, Charles; Luik, Peter T; Kerschbaum, Julia; Tiefenthaler, Martin; Watschinger, Bruno; Adema, Aaltje Y; Stepanov, Vadim A; Zulkarnaev, Alexey B; Turkmen, Kultigin; Decenzio, Bonucchi; Fliedner, Anselm; Miyasato, Hitoshi; Åsberg, Anders; Mjoen, Geir; Pini, Stefano; de Biase, Consuelo; van de Logt, Anne Els; Maas, Rutger; Lebedeva, Olga; Lopez, Veronica; Reichert, Louis J M; Verhave, Jacobien; Titov, Denis; Parshina, Ekaterina V; van Gils-Verrij, Liesbeth E A; de Bruin, Charlotte J R; Harty, John C; Meurs, Marleen; Myslak, Marek; Battaglia, Yuri; Lentini, Paolo; den Deurwaarder, Edwin; Rahimzadeh, Hormat; Schouten, Marcel; Cabezas-Reina, Carlos J; Diaz-Mareque, Anabel; Coca, Armando; Meijers, Björn K I; Naesens, Maarten; Kuypers, Dirk; Desschans, Bruno; Tonnerlier, Annelies; Wissing, Karl M; Dedinska, Ivana; Pessolano, Giuseppina; van der Sande, Frank M; Christiaans, Maarten H L; Gandolfini, Ilaria; Maggiore, Umberto; Kanaan, Nada; Labriola, Laura; Devresse, Arnaud; Malik, Shafi; Berger, Stefan P; Meijer, Esther; Sanders, Jan Stephan F; Ponikvar, Jadranka Buturović; Abrahams, Alferso C; Molenaar, Femke M; van Zuilen, Arjan D; Meijvis, S C A; Dolmans, Helma; Zanoli, Luca; Marcantoni, Carmelita; Esposito, Pasquale; Krzesinski, Jean-Marie; Barahira, Jean Damacène; Gallieni, Maurizio; Martin-Moreno, Paloma Leticia; Guglielmetti, Gabriele; Guzzo, Gabriella; Luik, Antinus J; van Kuijk, Willi H M; Stikkelbroeck, Lonneke W H; Hermans, Marc M H; Rimsevicius, Laurynas; Righetti, Marco; Braak, Nicole Heitink-ter | |
| dc.date.accessioned | 2022-03-02T05:44:24Z | |
| dc.date.accessioned | 2026-01-11T05:57:03Z | |
| dc.date.available | 2022-03-02T05:44:24Z | |
| dc.date.issued | 2020-11-01 | |
| dc.description.abstract | Abstract Background. Patients on kidney replacement therapy comprise a vulnerable population and may be at increased risk of death from coronavirus disease 2019 (COVID-19). Currently, only limited data are available on outcomes in this patient population. Methods. We set up the ERACODA (European Renal Association COVID-19 Database) database, which is specifically designed to prospectively collect detailed data on kidney transplant and dialysis patients with COVID-19. For this analysis, patients were included who presented between 1 February and 1 May 2020 and had complete information available on the primary outcome parameter, 28-day mortality. Results. Of the 1073 patients enrolled, 305 (28%) were kidney transplant and 768 (72%) dialysis patients with a mean age of 60 ± 13 and 67 ± 14 years, respectively. The 28-day probability of death was 21.3% [95% confidence interval (95% CI) 14.3–30.2%] in kidney transplant and 25.0% (95% CI 20.2–30.0%) in dialysis patients. Mortality was primarily associated with advanced age in kidney transplant patients, and with age and frailty in dialysis patients. After adjusting for sex, age and frailty, in-hospital mortality did not significantly differ between transplant and dialysis patients [hazard ratio (HR) 0.81, 95% CI 0.59–1.10, P = 0.18]. In the subset of dialysis patients who were a candidate for transplantation (n = 148), 8 patients died within 28 days, as compared with 7 deaths in 23 patients who underwent a kidney transplantation <1 year before presentation (HR adjusted for sex, age and frailty 0.20, 95% CI 0.07–0.56, P < 0.01). Conclusions. The 28-day case-fatality rate is high in patients on kidney replacement therapy with COVID-19 and is primarily driven by the risk factors age and frailty. Furthermore, in the first year after kidney transplantation, patients may be at increased risk of COVID-19-related mortality as compared with dialysis patients on the waiting list for transplantation. This information is important in guiding clinical decision-making, and for informing the public and healthcare authorities on the COVID-19-related mortality risk in kidney transplant and dialysis patients. | |
| dc.identifier.doi | 10.1093/ndt/gfaa261 | |
| dc.identifier.issn | 0931-0509, 1460-2385 | |
| dc.identifier.issue | 11 | |
| dc.identifier.pages | 1973-1983 | |
| dc.identifier.uri | https://hdl.handle.net/11424/218802 | |
| dc.identifier.volume | 35 | |
| dc.language.iso | eng | |
| dc.relation.uri | https://academic.oup.com/ndt/article/35/11/1973/5956894 | |
| dc.title | COVID-19-related mortality in kidney transplant and dialysis patients: results of the ERACODA collaboration | |
| dc.title.alternative | COVID-19-related mortality in kidney transplant and dialysis patients | |
| dc.type | article | |
| dspace.entity.type | Publication |
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