Publication: Neuroendocrine differentiation in non-neuroendocrine thyroid carcinoma
| dc.contributor.authors | Kargi, A; Yorukoglu, K; Aktas, S; Cakalagaoglu, F; Ermete, M | |
| dc.date.accessioned | 2022-03-12T16:57:19Z | |
| dc.date.accessioned | 2026-01-10T19:15:49Z | |
| dc.date.available | 2022-03-12T16:57:19Z | |
| dc.date.issued | 1996 | |
| dc.description.abstract | Specimens from 40 cases of thyroid carcinomas, including 35 papillary, 2 follicular, 2 undifferentiated, and 1 Hurtle cell carcinoma were analyzed for neuroendocrine differentiation with immunohistochemical tests for synapthophysin, neuron-specific enolase (NSE), chromogranin, and calcitonin; all cases were stained for thyroglobulin. Histologically, none of the cases resembled a medullary carcinoma. Twenty-five percent (10 cases) were immunoreactive for one, 30% (12 cases) for two, and 15% (6 cases) for three markers. Three of the cases that were positive for all 3 markers (7.5% of all total) had diffuse strong immunoreactivity. These results demonstrated neuroendocrine differentiation may occur in non-neuroendocrine thyroid tumors and may support the postulation that endodermally derived ultimobronchial stem cells might give rise to C cells as well as follicular cells. | |
| dc.identifier.doi | doiWOS:A1996UZ44100009 | |
| dc.identifier.issn | 1050-7256 | |
| dc.identifier.pubmed | 8837328 | |
| dc.identifier.uri | https://hdl.handle.net/11424/226920 | |
| dc.identifier.wos | WOS:A1996UZ44100009 | |
| dc.language.iso | eng | |
| dc.publisher | MARY ANN LIEBERT INC PUBL | |
| dc.relation.ispartof | THYROID | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | MEDULLARY | |
| dc.subject | ENDOCRINE | |
| dc.title | Neuroendocrine differentiation in non-neuroendocrine thyroid carcinoma | |
| dc.type | article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 210 | |
| oaire.citation.issue | 3 | |
| oaire.citation.startPage | 207 | |
| oaire.citation.title | THYROID | |
| oaire.citation.volume | 6 |