Publication: In vitro microsomal metabolism of nuclear chloro substituted secondary amines and imines
| dc.contributor.authors | Kůçükgüzel I., Ülgen M., Gorrod J.W. | |
| dc.date.accessioned | 2022-03-15T01:53:22Z | |
| dc.date.accessioned | 2026-01-10T18:39:20Z | |
| dc.date.available | 2022-03-15T01:53:22Z | |
| dc.date.issued | 1997 | |
| dc.description.abstract | The metabolism of N-(4-chlorobenzyl)-4-chloroaniline (CBCA), N-(4-chlorobenzyl)-4-chlorobenzylamine (CBCBA), and N-(4-chlorobenzylidene)-4-chlorobenzylamine (CBDCBA) were studied in vitro using rat liver microsomal preparations. The secondary amines produced the corresponding N-oxidation products (hydroxylamines and nitrones) and dealkylation products (4-chlorobenzaldehyde and primary amines). Both secondary amines failed to produce the corresponding amides, whilst the parent imine was detected as a metabonate. CBDCBA, the intermediate imine of CBCBA metabolism, was also incubated under similar conditions. However, no oxaziridine was detected. | |
| dc.identifier.doi | 10.1007/BF03190970 | |
| dc.identifier.issn | 3787966 | |
| dc.identifier.uri | https://hdl.handle.net/11424/246318 | |
| dc.language.iso | eng | |
| dc.publisher | Springer-Verlag France | |
| dc.relation.ispartof | European Journal of Drug Metabolism and Pharmacokinetics | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | Hydroxylamines | |
| dc.subject | Metabolism | |
| dc.subject | Nitrones | |
| dc.subject | Oxaziridines | |
| dc.subject | Secondary amines | |
| dc.title | In vitro microsomal metabolism of nuclear chloro substituted secondary amines and imines | |
| dc.type | conferenceObject | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 358 | |
| oaire.citation.issue | 4 | |
| oaire.citation.startPage | 351 | |
| oaire.citation.title | European Journal of Drug Metabolism and Pharmacokinetics | |
| oaire.citation.volume | 22 |