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Association of PD-1 and PDL-1 gene polymorphisms with colorectal cancer risk and prognosis

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dc.contributor.authorKARAALP, ATİLA
dc.contributor.authorSÜSLEYİCİ, BELGİN
dc.contributor.authorsCevik M., Namal E., Iner-Koksal U., Dinc-Sener N., KARAALP A., Ciftci C., SÜSLEYİCİ B.
dc.date.accessioned2023-02-13T13:06:12Z
dc.date.accessioned2026-01-10T20:30:57Z
dc.date.available2023-02-13T13:06:12Z
dc.date.issued2022-03-01
dc.description.abstractBackground Programmed Cell Death-1 (PD-1) together with Programmed Death Ligand 1 (PDL-1) have crucial roles in anti-tumor immune response, cancer susceptibility and prognosis. Since PD-1 and PDL-1 have been considered as important genetic risk factors in cancer development and their functions can be affected by polymorphic sites, we investigated the effects of PD-1 rs2227981, rs2227982, rs36084323 and PDL-1 rs2282055, rs822336 gene polymorphisms on colorectal cancer (CRC) risk and prognosis in Turkish subjects. Methods and results Our study group consisted of 5-FU or Capacitabine prescribed CRC diagnosed patients and healthy controls. Genotype analyses of PD1 and PDL-1 polymorphisms were performed with Agena MassARRAY platform. rs36084323 CT genotype frequency was found to be higher in controls compared to cases (p C polymorphism might be useful in predicting CRC prognosis. PDL-1 rs2282055 T > G polymorphism might be useful in predicting both CRC risk and prognosis. Further studies should be conducted in larger and different populations to clear the roles of PD-1 and PDL-1 polymorphisms in CRC risk and prognosis.
dc.identifier.citationCevik M., Namal E., Iner-Koksal U., Dinc-Sener N., KARAALP A., Ciftci C., SÜSLEYİCİ B., "Association of PD-1 and PDL-1 gene polymorphisms with colorectal cancer risk and prognosis", MOLECULAR BIOLOGY REPORTS, cilt.49, sa.3, ss.1827-1836, 2022
dc.identifier.doi10.1007/s11033-021-06992-9
dc.identifier.endpage1836
dc.identifier.issn0301-4851
dc.identifier.issue3
dc.identifier.startpage1827
dc.identifier.urihttps://hdl.handle.net/11424/286140
dc.identifier.volume49
dc.language.isoeng
dc.relation.ispartofMOLECULAR BIOLOGY REPORTS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectLife Sciences
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectNatural Sciences
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectBIOCHEMISTRY & MOLECULAR BIOLOGY
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectLife Sciences (LIFE)
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectClinical Biochemistry
dc.subjectCancer Research
dc.subjectMolecular Biology
dc.subjectDrug Discovery
dc.subjectAging
dc.subjectGeneral Biochemistry, Genetics and Molecular Biology
dc.subjectBiochemistry
dc.subjectStructural Biology
dc.subjectColorectal cancer
dc.subjectImmune check point
dc.subjectPD-1
dc.subjectPDL-1
dc.subjectrs36084323
dc.subjectrs822336
dc.subjectrs2282055
dc.subjectCELL LUNG-CANCER
dc.subjectINDUCED EXPRESSION
dc.subjectIMMUNE ESCAPE
dc.subjectBREAST-CANCER
dc.subjectTUMOR-CELLS
dc.subjectPD1 GENE
dc.subjectSUSCEPTIBILITY
dc.subjectPD-1/PD-L1
dc.subjectCHILDREN
dc.subjectPATHWAY
dc.titleAssociation of PD-1 and PDL-1 gene polymorphisms with colorectal cancer risk and prognosis
dc.typearticle
dspace.entity.typePublication

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