Publication:
A three-component, one-pot synthesis of 1,8-naphthyridine and isoxazole derivatives and computational elucidation of the mechanism

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dc.contributor.authorERDEM, SAFİYE
dc.contributor.authorsGuleli, Muge; Erdem, Safiye S.; Ocal, Nuket; Erden, Ihsan; Sari, Ozlem
dc.date.accessioned2022-03-12T22:39:14Z
dc.date.accessioned2026-01-11T19:12:49Z
dc.date.available2022-03-12T22:39:14Z
dc.date.issued2019
dc.description.abstractAn efficient and general method for the synthesis of substituted 3,4-dimethylisoxazolo[5,4-b]pyridine-5-carboxamide and benzo[b][1,8]naphthyridine-3-carboxamide derivatives by using 2,2,6-trimethyl-4H-1,3-dioxin-4-one, benzyl amine, aromatic aldehydes, 2-aminoquinoline, or 5-amino-3-methylisoxazole in the presence of a catalytic amount of p-toluenesulfonic acid or iodine is described. The formation of the products was investigated and the results obtained were also supported by theoretical calculations.
dc.identifier.doi10.1007/s11164-018-03721-z
dc.identifier.eissn1568-5675
dc.identifier.issn0922-6168
dc.identifier.urihttps://hdl.handle.net/11424/235789
dc.identifier.wosWOS:000461305200025
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofRESEARCH ON CHEMICAL INTERMEDIATES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIsoxazoles
dc.subject1,8-Naphthyridines
dc.subjectCatalyst
dc.subjectConjugated heterocycles
dc.subjectComputational studies
dc.subjectPATH
dc.subjectAROMATICITY
dc.subjectCONTINUUM
dc.subjectOXIDATION
dc.subjectKINETICS
dc.subjectANALOGS
dc.titleA three-component, one-pot synthesis of 1,8-naphthyridine and isoxazole derivatives and computational elucidation of the mechanism
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage2134
oaire.citation.issue4
oaire.citation.startPage2119
oaire.citation.titleRESEARCH ON CHEMICAL INTERMEDIATES
oaire.citation.volume45

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