PARTIAL CHARACTERIZATION OF AN INHIBITOR OF PROTEIN-SYNTHESIS IN RABBIT ERYTHROCYTES - ITS RELATIONSHIP TO THE OXIDATIVE STRESS ACTIVATED INHIBITOR IN RABBIT RETICULOCYTES

Abstract

An inhibitor of protein synthesis has been shown to be activated in in rabbit reticulocytes under various stress conditions like high oxygen partial pressure, presence of glutathione disulfide or heat treatment (1). Glucose-6-phosphate prevents this activation. The present study shows that a related inhibitor is present in rabbit erythrocytes in an active state already without exerted stress. The activation of the inhibitor is discussed in terms of its possible role in the final erythrocyte maturation.