Publication: Tip 2 diyabetes mellitus hastalarında retinopati trombosit membranı anyonik yükü ile ilişkili midir?
Abstract
Amaç: Bu çalışmada nefropatisi olmayan tip 2 diyabet hastalarında değişik evrelerdeki diyabetik retinopatinin (DR) kontrol grubu ile karşılaştırmalı olarak trombosit anyonik yükü ile ilişkisini değerlendirmeyi amaçladık. Gereç ve Yöntem: Bu çalışmaya dahil edilen 49 tip 2 diyabet hastası aile hekimliğine başvurularında tespit edilen kontrolsüz olgulardı. Çalışmada ilk muayene bulgularına dayanarak retinopati derecesine göre 3 gruba ayrıldı: Grup A (n=23) retinopatisi olmayan, grup B (n=13) preproliferatif DR, grup C (n=13) proliferatif DR. 38 diyabetik olmayan vaka kontrol grubu olarak seçildi (grup D). Trombosit anyonik yükü (TAY) trombositlerin alcian blue bağlamasına göre ölçüldü. Bulgular: Tip 2 diyabet hastaları kontrol grubuna göre istatistiksel olarak anlamlı düzeyde düşük TAY'e sahipti (p<0.05). Proliferatif DR hasta grubunda ölçülen TAY değerleri ne preproliferatif DR grubu ne de retinopati olmayan gruba göre istatistiksel olarak anlamlı düzeyde farklı değildi. Sonuç: Bizim çalışmamızda TAY düzeyleri diabetik hastalarda normal kontrol göre düşük tespit edilmiştir. TAY düzeyi ile retinopati derecesi arasında anlamlı bir ilişki yoktur.
Purpose: Our purpose is to evaluate the relationship between the platelet membrane anionic charge (PAC) and different stages of diabetic retinopathy (DR) in nephropathy-free patients with type 2 diabetes mellitus with the PAC in non-diabetic control subjects. Materials and Methods: Forty-nine patients with type 2 diabetes attended to the family physician for the first time were included in this study. Depending on the first ophthalmic examination they were divided by the stage of DR into 3 groups: Group A (n=23), those without DR; group B (n=13), those with pre-proliferative DR; and group C (n=13), those with proliferative DR. 38 nondiabetic subjects made up the control group (group D). Platelet anionic charge (PAC) was measured as alcian blue binding to platelets. Results: The patients with type 2 diabetes had significantly lower levels of platelet anionic charges than the non-diabetic controls (p<0.05). PAC in the patients with proliferative DR were not significantly different from neither that in non-proliferative nor in no DR group. Conclusion: Our study demonstrated decreased levels of PAC in diabetic patients as compared with non-diabetic controls. There is no relationship between PAC and DR severity.
Purpose: Our purpose is to evaluate the relationship between the platelet membrane anionic charge (PAC) and different stages of diabetic retinopathy (DR) in nephropathy-free patients with type 2 diabetes mellitus with the PAC in non-diabetic control subjects. Materials and Methods: Forty-nine patients with type 2 diabetes attended to the family physician for the first time were included in this study. Depending on the first ophthalmic examination they were divided by the stage of DR into 3 groups: Group A (n=23), those without DR; group B (n=13), those with pre-proliferative DR; and group C (n=13), those with proliferative DR. 38 nondiabetic subjects made up the control group (group D). Platelet anionic charge (PAC) was measured as alcian blue binding to platelets. Results: The patients with type 2 diabetes had significantly lower levels of platelet anionic charges than the non-diabetic controls (p<0.05). PAC in the patients with proliferative DR were not significantly different from neither that in non-proliferative nor in no DR group. Conclusion: Our study demonstrated decreased levels of PAC in diabetic patients as compared with non-diabetic controls. There is no relationship between PAC and DR severity.