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Proteomic analysis in nifedipine induced gingival overgrowth: A pilot study

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dc.contributor.authorYARAT, AYŞEN
dc.contributor.authorÖZTÜRK ÖZENER, HAFİZE
dc.contributor.authorKURU, LEYLA
dc.contributor.authorsYETİŞ E., YARAT A., Eroğlu O., ÖZTÜRK H., KURU L.
dc.date.accessioned2023-01-26T06:58:03Z
dc.date.available2023-01-26T06:58:03Z
dc.date.issued2022-12-01
dc.description.abstractObjective: The aims of the present study were to investigate the proteomic profile of nifedipine induced overgrown gingiva and compare with non-overgrown gingival tissues obtained from the same patients. Methods: Seven subjects under nifedipine medication for at least 6 months and diagnosed as nifedipine induced gingival overgrowth (NIGO) participated in the study. Periodontal clinical parameters were recorded. Gingival tissue samples were harvested from overgrown (GO+ Group, n=7) and non-overgrown regions (GO- Group, n=7) of the same patients. Proteomics was performed using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) technique. The identified proteins were further classified according to their molecular functions, biological processes and cellular component distribution for functional gene ontology analysis using a web-based bioinformatics tool. Mann Whitney-U and ANOVA tests were performed to compare clinical parameters and identified proteins with proteomics, respectively. Results: Bleeding on probing and gingival overgrowth index of the GO+ group were statistically significantly higher than the GO- group (p<0.05, p<0.01, respectively). A total of 143 proteins were identified in 14 gingival tissue samples using proteomics. Among the proteins identified, 79 of them were detected in higher quantities in the GO+ group (p<0.05) whereas remaining 64 were found higher in the GO- group (p<0.05). The analysis of functional gene ontology demonstrated that certain proteins exhibit roles in either stimulatory or inhibitory processes including cell proliferation, growth and apoptosis. Conclusion: The proteomic profiles of overgrown and non-overgrown gingiva suggest that the identified proteins expressed at different levels in both groups may contribute to the pathogenesis and progression of NIGO.
dc.identifier.citationYETİŞ E., YARAT A., Eroğlu O., ÖZTÜRK H., KURU L., "Proteomic Analysis in Nifedipine Induced Gingival Overgrowth: A Pilot Study", CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.12, sa.4, ss.1013-1024, 2022
dc.identifier.endpage1024
dc.identifier.issn2459-1459
dc.identifier.issue4
dc.identifier.startpage1013
dc.identifier.urihttps://dergipark.org.tr/en/pub/clinexphealthsci/issue/73168/1050418
dc.identifier.urihttps://hdl.handle.net/11424/285878
dc.identifier.volume12
dc.language.isoeng
dc.relation.ispartofCLINICAL AND EXPERIMENTAL HEALTH SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectgingival overgrowth
dc.subjectnifedipine
dc.subjectproteomics
dc.titleProteomic analysis in nifedipine induced gingival overgrowth: A pilot study
dc.typearticle
dspace.entity.typePublication
local.avesis.id7398ed3c-42cf-4ac7-b120-b6922b1aa5e9
relation.isAuthorOfPublication46115086-6b46-4ef8-aaf1-ab8eda3e917e
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relation.isAuthorOfPublication.latestForDiscovery46115086-6b46-4ef8-aaf1-ab8eda3e917e

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