Publication:
A study on ester thiosemicarbazones

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1997

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Abstract

The cyclization of ester thiosemicarbazones to two different heterocycles was studied for some new thiosemicarbazones, and only the formation of 1,2,4-triazol-5-thiols was attributed to the regioselectivity of the ring closure reaction, due to a steric hindrance of bulky groups. Next, some of the new compounds were tested for their in vitro antimicrobial and antitumor activities.

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1,2,4-triazol-5-thiols, 1,3,4-thiadiazoles, 4,5-dihydro-1h-1,2,4-triazol-5-thiones, Biological activity, Ester thiosemicarbazones, Synthesis

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https://hdl.handle.net/11424/255377

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