Publication:
Involvement of Neuroactive Steroids in Pain, Depression and Anxiety

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dc.contributor.authorARICIOĞLU, FEYZA
dc.contributor.authorsMifflin, Katherine; Benson, Curtis; Kerr, Bradley; Aricioglu, Feyza; Cetin, Mesut; Dursun, Serdar; Baker, Glen
dc.contributor.editorFinn, DP
dc.contributor.editorLeonard, BE
dc.date.accessioned2022-03-11T21:33:48Z
dc.date.accessioned2026-01-11T06:30:36Z
dc.date.available2022-03-11T21:33:48Z
dc.date.issued2015
dc.description.abstractComorbidity between major depressive disorder (MDD), anxiety (generalized anxiety, panic disorder, social anxiety disorder) and pain is a major complicating factor in the diagnosis and treatment of psychiatric and neurological disorders. Although numerous neurotransmitters and/or neuromodulators may be involved, abnormalities in the GABAergic and glutamatergic systems seem to be a common factor in all these disorders. Neuroactive steroids (NASs) have been the object of considerable interest in this area in recent years since they appear to act predominantly on GABA-A and glutamate NMDA receptors. An overview of the possible involvement of NASs in MDD, anxiety and pain is provided in this chapter. (C) 2015 S. Karger AG, Basel
dc.identifier.bookdoi10.1159/isbn.978-3-318-05574-0
dc.identifier.doi10.1159/000435935
dc.identifier.isbn978-3-318-05574-0; 978-3-318-05573-3
dc.identifier.issn1662-2685
dc.identifier.pubmed26436548
dc.identifier.urihttps://hdl.handle.net/11424/222811
dc.identifier.wosWOS:000389019100008
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofPAIN IN PSYCHIATRIC DISORDERS
dc.relation.ispartofseriesModern Trends in Pharmacopsychiatry
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNEUROPATHIC PAIN
dc.subjectSPINAL-CORD
dc.subjectGLUTAMATE TRANSPORTERS
dc.subjectGABA(A) RECEPTORS
dc.subjectGENE-EXPRESSION
dc.subjectDISORDERS
dc.subjectPROGESTERONE
dc.subjectRATS
dc.subjectNEUROSTEROIDS
dc.subjectINHIBITION
dc.titleInvolvement of Neuroactive Steroids in Pain, Depression and Anxiety
dc.typebookPart
dspace.entity.typePublication
oaire.citation.endPage102
oaire.citation.startPage94
oaire.citation.titlePAIN IN PSYCHIATRIC DISORDERS
oaire.citation.volume30

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