Publication:
Development of self-healing vanillin/PEI hydrogels for tissue engineering

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dc.contributor.authorOKTAY, BURCU
dc.contributor.authorKAYAMAN APOHAN, NİLHAN
dc.contributor.authorsYasar M., OKTAY B., Dal Yontem F., Haciosmanoglu Aldogan E., KAYAMAN APOHAN N.
dc.date.accessioned2023-03-07T11:15:52Z
dc.date.accessioned2026-01-11T08:06:54Z
dc.date.available2023-03-07T11:15:52Z
dc.date.issued2023-04-20
dc.description.abstractSelf-healing materials recover mechanical damages to expand the lifetime of the material provided. In this study, self-healing hydrogels have been successfully prepared using a novel and simple technique. Vanillin is a natural monomer, used as a bio-based cross-linker for UV-induced bonding and Schiff-base bonding. Methacrylate-functionalized vanillin (M-VAN) is covalently integrated with the polymer matrix. While M-VAN supports polymer matrix with its vinyl group, its aldehyde functionality helps the formation of dynamic covalent imine bonds via Schiff-base formation. The hydrogel showed excellent self-healing ability overnight under physiological conditions without external addition. In addition, the hydrogel surface was modified by collagen and its cell viability was investigated. The prepared scaffolds showed good cell viability of 124% and 163% compared to the control sample. The developed self-healing material reveals that it has possible uses for future biomedical applications and tissue engineering studies due to the self-healing mechanism taking place under ambient conditions.
dc.identifier.citationYasar M., OKTAY B., Dal Yontem F., Haciosmanoglu Aldogan E., KAYAMAN APOHAN N., "Development of self-healing vanillin/PEI hydrogels for tissue engineering", European Polymer Journal, cilt.188, 2023
dc.identifier.doi10.1016/j.eurpolymj.2023.111933
dc.identifier.endpage11
dc.identifier.issn0014-3057
dc.identifier.startpage1
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85148539590&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/287264
dc.identifier.volume188
dc.language.isoeng
dc.relation.ispartofEuropean Polymer Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFizik
dc.subjectAstronomi ve Astrofizik
dc.subjectKimya
dc.subjectBiyokimya
dc.subjectBiyoinorganik Kimya
dc.subjectFizikokimya
dc.subjectPolimer Karakterizasyonu
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectPhysics
dc.subjectAstronomy and Astrophysics
dc.subjectChemistry
dc.subjectBiochemistry
dc.subjectBioinorganic Chemistry
dc.subjectPhysical Chemistry
dc.subjectCharacterization of Polymers
dc.subjectNatural Sciences
dc.subjectEngineering and Technology
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectTemel Bilimler (SCI)
dc.subjectMalzeme Bilimi
dc.subjectUzay bilimi
dc.subjectPOLİMER BİLİMİ
dc.subjectKİMYA, ORGANİK
dc.subjectASTRONOMİ VE ASTROFİZİK
dc.subjectMALZEME BİLİMİ, ÇOKDİSİPLİNLİ
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectNatural Sciences (SCI)
dc.subjectMATERIALS SCIENCE
dc.subjectCHEMISTRY
dc.subjectSPACE SCIENCE
dc.subjectPOLYMER SCIENCE
dc.subjectCHEMISTRY, ORGANIC
dc.subjectASTRONOMY & ASTROPHYSICS
dc.subjectMATERIALS SCIENCE, MULTIDISCIPLINARY
dc.subjectGenel Fizik ve Astronomi
dc.subjectFizik Bilimleri
dc.subjectPolimerler ve Plastikler
dc.subjectOrganik Kimya
dc.subjectMalzeme Kimyası
dc.subjectGeneral Physics and Astronomy
dc.subjectPhysical Sciences
dc.subjectPolymers and Plastics
dc.subjectOrganic Chemistry
dc.subjectMaterials Chemistry
dc.subjectHydrogels
dc.subjectSelf-healing
dc.subjectUV-polymerization
dc.subjectVanillin
dc.subjectHydrogels
dc.subjectSelf-healing
dc.subjectUV-polymerization
dc.subjectVanillin
dc.titleDevelopment of self-healing vanillin/PEI hydrogels for tissue engineering
dc.typearticle
dspace.entity.typePublication

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