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Sequential Triplex Real-Time PCR Assay for Detecting 21 Pneumococcal Capsular Serotypes That Account for a High Global Disease Burden

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dc.contributor.authorsPimenta, Fabiana C.; Roundtree, Alexis; Soysal, Ahmet; Bakir, Mustafa; du Plessis, Mignon; Wolter, Nicole; von Gottberg, Anne; McGee, Lesley; Carvalho, Maria da Gloria; Beall, Bernard
dc.date.accessioned2022-03-14T10:56:16Z
dc.date.accessioned2026-01-11T15:16:05Z
dc.date.available2022-03-14T10:56:16Z
dc.date.issued2013-02-01
dc.description.abstractWe developed and validated a real-time PCR assay consisting of 7 triplexed reactions to identify 11 individual serotypes plus 10 small serogroups representing the majority of disease-causing isolates of Streptococcus pneumoniae. This assay targets the 13 serotypes included within the 13-valent conjugate vaccine and 8 additional key serotypes or serogroups. Advantages over other serotyping assays are described. The assay will be expanded to 40 serotypes/serogroups. We will provide periodic updates at our protocol website.
dc.identifier.doi10.1128/JCM.02927-12
dc.identifier.eissn1098-660X
dc.identifier.issn0095-1137
dc.identifier.pubmed23224094
dc.identifier.urihttps://hdl.handle.net/11424/245524
dc.identifier.wosWOS:000314108000046
dc.language.isoeng
dc.publisherAMER SOC MICROBIOLOGY
dc.relation.ispartofJOURNAL OF CLINICAL MICROBIOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSTREPTOCOCCUS-PNEUMONIAE SEROTYPES
dc.subjectMULTIPLEX PCR
dc.subjectINVASIVE DISEASE
dc.subjectIDENTIFICATION
dc.subjectDIAGNOSIS
dc.subjectCHILDREN
dc.subjectSAMPLES
dc.subject6A
dc.titleSequential Triplex Real-Time PCR Assay for Detecting 21 Pneumococcal Capsular Serotypes That Account for a High Global Disease Burden
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage652
oaire.citation.issue2
oaire.citation.startPage647
oaire.citation.titleJOURNAL OF CLINICAL MICROBIOLOGY
oaire.citation.volume51

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