Publication:
Effects of fluoxetine-induced hyperprolactinaemia on adenomyosis induction in Wistar Albino rats

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dc.contributor.authorsFicicioglu, C; Tekin, HI; Arioglu, PF; Okar, I
dc.date.accessioned2022-03-12T16:56:45Z
dc.date.accessioned2026-01-11T13:15:17Z
dc.date.available2022-03-12T16:56:45Z
dc.date.issued1996
dc.description.abstractFluoxetine, a serotonin reuptake inhibitors was administered to groups of overiectomised and intact Wistar rats for 14 weeks. Controls received a placebo. At the end of the experimental period the animals were decapitated. Prolactin was measured in the separated plasma and the uteri examined by light microscopy. Prolactin levels were significantly higher in those rats treated with fluoxetine. 11 out of 12 intact rats given fluoxetine exhibited endometrial stromal invasion. It is suggested that high circulating levels of prolactin lead to degeneration of myometrial cells in the presence of ovarian steroids. This could result in myometrial invasion by endometrial stroma and eventually progress to adenomyosis.
dc.identifier.doidoiWOS:A1996VD00400017
dc.identifier.issn0269-8951
dc.identifier.urihttps://hdl.handle.net/11424/226834
dc.identifier.wosWOS:A1996VD00400017
dc.language.isoeng
dc.publisherCHAPMAN HALL LTD
dc.relation.ispartofMEDICAL SCIENCE RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectadenomyosis
dc.subjectfluoxetine
dc.subjecthyperprolactinaemia
dc.subjectUTERINE ADENOMYOSIS
dc.subjectPROLACTIN
dc.subjectMICE
dc.subjectRELEASE
dc.titleEffects of fluoxetine-induced hyperprolactinaemia on adenomyosis induction in Wistar Albino rats
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage559
oaire.citation.issue8
oaire.citation.startPage557
oaire.citation.titleMEDICAL SCIENCE RESEARCH
oaire.citation.volume24

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