Publication:
Evaluation of the analgesic and anti-inflammatory activities of some thiazolo[4,5-d]pyrimidines

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dc.contributor.authorsBalkan, A; Goren, Z; Urgun, H; Calis, U; Cakar, AN; Atilla, P; Uzbay, T
dc.date.accessioned2022-03-12T17:01:58Z
dc.date.accessioned2026-01-11T10:29:19Z
dc.date.available2022-03-12T17:01:58Z
dc.date.issued2002
dc.description.abstractSome thiazolo[4,5-d]pyrimidine-7(6H)one derivatives were evaluated in vivo for their analgesic and anti-inflammatory activities. The results were compared with that of acetyl salicylic acid and phenylbutazone. Compounds 3b and 3h were the most active in the anti-inflammatory paw edema inhibition test. In terms of the analgesic activity (acetic acid writhing test), the most active compound was 2a followed by 3I. The most active members of the series were investigated for their ED50 values and ulcerogenic potential.
dc.identifier.doidoiWOS:000176638000007
dc.identifier.issn0004-4172
dc.identifier.pubmed12109047
dc.identifier.urihttps://hdl.handle.net/11424/227431
dc.identifier.wosWOS:000176638000007
dc.language.isoeng
dc.publisherECV-EDITIO CANTOR VERLAG MEDIZIN NATURWISSENSCHAFTEN
dc.relation.ispartofARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectanti-inflammatories, non-steroidal
dc.subjectthiazolo[4,5-d]pyrimidines, analgesic activity, anti-inflammatory activity
dc.subjectSYNOVIAL TISSUES
dc.subjectCYCLOOXYGENASE
dc.subjectDERIVATIVES
dc.subjectEXPRESSION
dc.subjectAGENTS
dc.titleEvaluation of the analgesic and anti-inflammatory activities of some thiazolo[4,5-d]pyrimidines
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage467
oaire.citation.issue6
oaire.citation.startPage462
oaire.citation.titleARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
oaire.citation.volume52

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