Publication: Büllöz akciğer hastalığı ve sigara: Postmortem çalışma
Abstract
Bu çalışma toplumumuzda sigara içimiyle büllöz akciğer hastalığı arasındaki ilişkiyi göstermek amacıyla yapılmıştır. Akciğer hasarı olmayan, bilinen akciğer hastalığı bulunmayan ve yakınlarından sigara kullanım öyküleri alınabilen 89 otopsi olgusu (65'i erkek, 24'ü kadın) çalışmaya dahil edildi. Büllerin lokalizasyonları, büyüklükleri ve sayıları kaydedildi. Patolojik inceleme için akciğerlerden bilateral multipl wedge rezeksiyonlar yapıldı. 56 (%63) olguda büllöz amfizem saptanırken, 33 (%37) olguda parankimal patoloji görülmedi. Erkeklerde sigara kullanım oranı %80 idi ve bunların %70.8'inde büllöz parankimal patolojiler gelişmişti. Kadınlarda sigara kullanım oranı %25, büllöz parankimal patoloji oranı ise %41.7 idi. Büllöz patoloji erkeklerde istatistiksel olarak daha fazlaydı (p< 0.0001). Sigara içenlerin %77.6'sında büllöz patoloji saptanırken, %22.4'ünde akciğer parankimi normaldi. Sigara içmeyenlerdeyse bu oranlar sırasıyla %35.5 ve %64.5'ti. Büllöz akciğer hastalığı istatistiksel olarak sigara içenlerde daha fazlaydı (p= 0.0002). Solunumsal bir şikayete sebep olmasa bile, sigara kullanımı büllöz amfizematöz parankimal değişikliklere sebep olmaktadır. Sigara kullanım oranı yüksek olan toplumumuzda amfizematöz değişiklikler ve büllöz akciğer hastalığı gelişme riski yüksektir.
This autopsy-based study was performed to assess the relationship of bullous lung disease and cigarette smoking in the Turkish population. Eighty-nine (65 males, 24 females) cases, without any pulmonary injury or pulmonary disease, and whose smoking histories were reliable, were enrolled. The localization, size and numbers of bullae were noted. Multiple bilateral wedge resections were performed for pathological examination. The relationship of bullous pathology and cigarette smoking was investigated. Fifty-six (63%) had bullous emphysema, 33 (37%) had no parenchymal pathology. 80% of males were smokers, and 70.8% had bullous pathology; whereas 25% of females were smokers, and 10 (41.7%) had bullous pathology. Bullous pathology was statistically more common in males (p< 0.0001). 77.6% of smokers had bullous pathology, and 22.4% had normal pulmonary parenchyma, whereas 35.5% of non-smokers had bullous pathology, and 64.5% had normal pulmonary parenchyma. The bullous lung disease was statistically more common in smokers (p= 0.0002). Even without any respiratory complaint, smoking causes the development of bullous emphysematous pathologies. As the incidence of smoking is high in our population, emphysematous changes and bullous lung diseases are expected to be common.
This autopsy-based study was performed to assess the relationship of bullous lung disease and cigarette smoking in the Turkish population. Eighty-nine (65 males, 24 females) cases, without any pulmonary injury or pulmonary disease, and whose smoking histories were reliable, were enrolled. The localization, size and numbers of bullae were noted. Multiple bilateral wedge resections were performed for pathological examination. The relationship of bullous pathology and cigarette smoking was investigated. Fifty-six (63%) had bullous emphysema, 33 (37%) had no parenchymal pathology. 80% of males were smokers, and 70.8% had bullous pathology; whereas 25% of females were smokers, and 10 (41.7%) had bullous pathology. Bullous pathology was statistically more common in males (p< 0.0001). 77.6% of smokers had bullous pathology, and 22.4% had normal pulmonary parenchyma, whereas 35.5% of non-smokers had bullous pathology, and 64.5% had normal pulmonary parenchyma. The bullous lung disease was statistically more common in smokers (p= 0.0002). Even without any respiratory complaint, smoking causes the development of bullous emphysematous pathologies. As the incidence of smoking is high in our population, emphysematous changes and bullous lung diseases are expected to be common.