Publication: Mast hücrelerinin enflamasyondaki rolü: İnsan ve deneysel hayvan modelleri üzerinde yapılan çalışmaların değerlendirilmesi
Abstract
Kemik iliğinden köken alan mast hücreleri sadece allerjik ve immunolojik reaksiyonlarda değil enflamasyon olaylarında da rol alan hücrelerdir. Bundan dolayı mast hücreleri sadece IgE’ye bağlı aktivasyonunun yanı sıra nörotransmiterler, ve sitokinlerle de aktive olarak granül içeriklerini ya da yeni sentezledikleri medyatörleri hücre dışına vererek enflamasyon reaksiyonlarında da rol alırlar. İnterstisiyel sistit, iltihabi barsak hastalığı ve atopik dermatit gibi bazı nöroenflamatuar hastalıklarda mast hücrelerinin alerjik reaksiyon olmadan aktive olduğu ve bu hastalıkların etiyolojisinde rol aldıkları düşünülmektedir. Bu derleme yazısında mesane, deri ve gastrointestinal sistemde insan ve deneysel hayvan modellerindeki enflamasyon reaksiyonlarında mast hücrelerinin rolü değerlendirilmiştir.
Mast cells derived from bone marrow have a pivotal role not only in allergic and immunologic reactions but also in inflammatory reactions. Hence, the mast cells besides the activation of IgE, are activated with neurotransmitters and cytokins. As a result of these reactions, the mast cells are activated and release the present granule contents or newly (de novo) synthesized mediators to extracellular environment, participating in the inflammatory reactions. Hence, in the pathogenesis of diseases such as interstitial cystitis, inflammatory bowel disease and atopic dermatitis where an allergic basis is not assumed, it was shown that mast cells are activated and play a role in the inflammation process. In this review, the leading role of mast cells in the urinary bladder, skin, and gastrointestinal system, is discussed and evaluated in human and animal models.
Mast cells derived from bone marrow have a pivotal role not only in allergic and immunologic reactions but also in inflammatory reactions. Hence, the mast cells besides the activation of IgE, are activated with neurotransmitters and cytokins. As a result of these reactions, the mast cells are activated and release the present granule contents or newly (de novo) synthesized mediators to extracellular environment, participating in the inflammatory reactions. Hence, in the pathogenesis of diseases such as interstitial cystitis, inflammatory bowel disease and atopic dermatitis where an allergic basis is not assumed, it was shown that mast cells are activated and play a role in the inflammation process. In this review, the leading role of mast cells in the urinary bladder, skin, and gastrointestinal system, is discussed and evaluated in human and animal models.