Anticonvulsant activity of some substituted 1,3,4-thiadiazoles

Abstract

Some 5-[4-(benzoylamino)phenyl]-2 substituted amino-1,3,4-thiadiazoles have been synthesized previously in our laboratory. The structures of these compounds were elucidated using UV, IR and Mass spectroscopic methods besides elemental analyses. In the present work, the structures of these compounds have also been supported by 1H-NMR and their anticonvulsant activities against pentylenetetrazole induced seizures in male and female Albino Swiss mice have been investigated. All the compounds showed protections ranging from 10 to 60% at a dose of l00 mg.kg-1 and among them, 2-allylamino-5-[4-(benzoylamino)phenyl]-l,3,4-thiadizole was found to posses significant protection against pentylenetetrazole shock.